ReviewThe American journal of Chinese medicine2011
Botanical flavonoids on coronary heart disease.
Review in The American journal of Chinese medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 79 citations in OpenAlex.
- Mechanism Repositioning Based on Integrative Pharmacology: Anti-Inflammatory Effect of Safflower in Myocardial Ischemia-Reperfusion Injury.International journal of molecular sciences · 2023Article
- Development of a Novel Apigenin Dosage form as a Substitute for the Modern Triple Antithrombotic Regimen.Molecules (Basel, Switzerland) · 2023Article
- Cardio-Oncology: Mechanisms, Drug Combinations, and Reverse Cardio-Oncology.International journal of molecular sciences · 2022Review
- Exploration of Lamiaceae in Cardio Vascular Diseases and Functional Foods: Medicine as Food and Food as Medicine.Frontiers in pharmacology · 2022Review
- Effect of Tongfu Xingshen capsule on the endogenous neural stem cells of experimental rats with intracerebral hemorrhage.Molecular medicine reports · 2021Article
- Change of Serum Metabolome and Cecal Microflora in Broiler Chickens Supplemented With Grape Seed Extracts.Frontiers in immunology · 2020Article
- 7-Biomolecules · 2019Article
- Therapeutic Effect ofEvidence-based complementary and alternative medicine : eCAM · 2019Article
- Impact of specific functional groups in flavonoids on the modulation of platelet activation.Scientific reports · 2018Article
- Regioselective Synthesis of Procyanidin B6, A 4-6-Condensed (+)-Catechin Dimer, by Intramolecular Condensation.Molecules (Basel, Switzerland) · 2018Article
- Dietary Supplements with Antiplatelet Activity: A Solution for Everyone?Advances in nutrition (Bethesda, Md.) · 2018Review
- The Effect of 3',4'-Dihydroxyflavonol on Lipid Peroxidation in Rats with Cerebral Ischemia Reperfusion Injury.Neurochemical research · 2016Article
- Exercise protects against PCB-induced inflammation and associated cardiovascular risk factors.Environmental science and pollution research international · 2016Article
- Vitexin exerts cardioprotective effect on chronic myocardial ischemia/reperfusion injury in rats via inhibiting myocardial apoptosis and lipid peroxidation.American journal of translational research · 2016Article
- Commonly Used Dietary Supplements on Coagulation Function during Surgery.Medicines (Basel, Switzerland) · 2015Article
- Baicalin attenuates alzheimer-like pathological changes and memory deficits induced by amyloid β1-42 protein.Metabolic brain disease · 2015Article
- Involvement of the GABAergic system in the neuroprotective and sedative effects of acacetin 7-O-glucoside in rodents.Restorative neurology and neuroscience · 2015Article
- Myrcia bella Leaf Extract Presents Hypoglycemic Activity via PI3k/Akt Insulin Signaling Pathway.Evidence-based complementary and alternative medicine : eCAM · 2014Article
- Pretreatment of baicalin and wogonoside with glycoside hydrolase: a promising approach to enhance anticancer potential.Oncology reports · 2013Article
- Different extraction pretreatments significantly change the flavonoid contents of Scutellaria baicalensis.Pharmaceutical biology · 2013Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Ischemic heart disease (IHD) is one of the leading causes of death in Western countries. Prevention rather than treatment of heart disease can significantly improve patients' quality of life and reduce health care costs. Flavonoids are widely distributed in vegetables, fruits and herbal medicines. Regularly consuming botanicals, especially those containing flavonoids, has been associated with a reduction in cardiovascualar disease; thus, it is important to investigate how flavonoids improve cardiac resistance to heart disease and their related mechanisms of action. It has been shown that cardiomyocyte injury and death can result from ischemia-reperfusion, which is pathognomonic of ischemic heart disease. Massive reactive oxygen species (ROS) release at the onset of reperfusion produces cell injury and death. "Programming" the heart to either generate less ROS or to increase strategic ROS removal could reduce reperfusion response. Additionally, profuse nitric oxide (NO) release at reperfusion could be protective in "preconditioning" models. Botanical flavonoids induce preconditioning of the heart, thereby protecting against ischemia-reperfusion injury. In this article, we will discuss two herbs containing potent flavonoids, Scutellaria baicalensis and grape seed proanthocyanidin, which can potentially offer cardiac protection against ischemic heart disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.