ArticleJournal of applied toxicology : JAT2012
Caffeine induction of sulfotransferases in rat liver and intestine.
Article in Journal of applied toxicology : JAT, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 22 citations in OpenAlex.
- Influence of methylxanthines isolated from Bancha green tea on the pharmacokinetics of sildenafil in rats.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2022Article
- The effects of oral administration of Cola nitida on the pharmacokinetic profile of metoclopramide in rabbits.BMC pharmacology & toxicology · 2020Article
- Article
- Estrogen Sulfotransferase Induction Inhibits Breast Cancer Cell Line MCF-7 Proliferation.Biomedical journal of scientific & technical research · 2019Article
- Multiple UDP-Glucuronosyltransferase and Sulfotransferase Enzymes are Responsible for the Metabolism of Verproside in Human Liver Preparations.Molecules (Basel, Switzerland) · 2017Article
- Guarana (Toxicology research · 2016Article
- Gender-Dependent Pharmacokinetics of Veratramine in Rats: In Vivo and In Vitro Evidence.The AAPS journal · 2016Article
- Modulation of Metabolic Detoxification Pathways Using Foods and Food-Derived Components: A Scientific Review with Clinical Application.Journal of nutrition and metabolism · 2015Review
- Pharmacogenomics, pharmacokinetics and pharmacodynamics: interaction with biological differences between men and women.British journal of pharmacology · 2014Review
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Sulfotransferases (SULTs) are important phase II drug-metabolizing enzymes. Regulation of SULTs by hormones and other endogenous molecules is relatively well understood, while xenobiotic induction of SULTs is not well studied. Caffeine is one of the most widely consumed psychoactive substances. However, SULT regulation by caffeine has not been reported. In this report, male and female rats were treated with different oral doses of caffeine (2, 10, 50 mg kg⁻¹ per day) for 7 days. Western blot and real-time RT-PCR were used to investigate the changes in SULT protein and mRNA expression following the caffeine treatment. Caffeine induced both rat aryl sulfotransferase (rSULT1A1, AST-IV) and rat hydroxysteroid sulfotransferase (rSULT2A1, STa) in the liver and intestine of female rats in a dose-dependent manner. Caffeine induction of rSULT1A1 and rSULT2A1 in the female rat intestine was much stronger than that in the liver. Although caffeine induced rSULT1A1 significantly in the male rat liver, it did not significantly induce rSULT2A1. In male rat intestine, caffeine significantly induced rSULT2A1. The different SULTs induction patterns in male and female rats suggest that the regulation of rat SULTs by caffeine may be affected by different hormone secretion patterns and levels. Our results suggest that consumption of caffeine can induce drug metabolizing SULTs in drug detoxification tissues.
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