Trial reportEuropean journal of applied physiology2012
Fluid intake and changes in limb volumes in male ultra-marathoners: does fluid overload lead to peripheral oedema?
Trial report in European journal of applied physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- Acute Kidney Injury and Hyponatremia in Ultra-Trail Racing: A Systematic Review.Medicina (Kaunas, Lithuania) · 2022Pooled it
- Physiology of lived experience: Cruising among the Swiss peaks.Experimental physiology · 2026Article
- Validity and Responsiveness of Measuring Facial Swelling With 3D Stereophotogrammetry in Patients After Bilateral Sagittal Split Osteotomy-A Prospective Clinimetric Study.International journal of biomedical imaging · 2025Article
- Exercise-Induced Fluid Retention, Cardiac Volume Overload, and Peripheral Edema in Ultra-Distance Cyclists.Kidney international reports · 2024Article
- Edema-like symptoms are common in ultra-distance cyclists and driven by overdrinking, use of analgesics and female sex - a study of 919 athletes.Journal of the International Society of Sports Nutrition · 2021Article
- Extreme Ultra-Trail Race Induces Muscular Damage, Risk for Acute Kidney Injury and Hyponatremia: A Case Report.International journal of environmental research and public health · 2021Article
- Changes in Factors Regulating Serum Sodium Homeostasis During Two Ultra-Endurance Mountain Races of Different Distances: 69km vs. 121km.Frontiers in physiology · 2021Article
- Exercise-Associated Hyponatremia in Endurance and Ultra-Endurance Performance-Aspects of Sex, Race Location, Ambient Temperature, Sports Discipline, and Length of Performance: A Narrative Review.Medicina (Kaunas, Lithuania) · 2019Review
- Body Composition Changes During a 24-h Winter Mountain Running Race Under Extremely Cold Conditions.Frontiers in physiology · 2019Article
- Nutrition in Ultra-Endurance: State of the Art.Nutrients · 2018Review
- Considerations in the Use of Body Mass Change to Estimate Change in Hydration Status During a 161-Kilometer Ultramarathon Running Competition.Sports medicine (Auckland, N.Z.) · 2018Article
- Copeptin reflects physiological strain during thermal stress.European journal of applied physiology · 2018Article
- Physiology and Pathophysiology in Ultra-Marathon Running.Frontiers in physiology · 2018Review
- Fluid retention, muscle damage, and altered body composition at the Ultraman triathlon.European journal of applied physiology · 2016Article
- Extreme Mountain Ultra-Marathon Leads to Acute but Transient Increase in Cerebral Water Diffusivity and Plasma Biomarkers Levels Changes.Frontiers in physiology · 2016Article
- The increase in hydric volume is associated to contractile impairment in the calf after the world's most extreme mountain ultra-marathon.Extreme physiology & medicine · 2015Article
- Serum copeptin and midregion proadrenomedullin (MR-proADM) after an ultramarathon.Journal of clinical laboratory analysis · 2015Article
- Feet swelling in a multistage ultraendurance triathlete: a case study.International journal of general medicine · 2015Article
- Changes in foot volume, body composition, and hydration status in male and female 24-hour ultra-mountain bikers.Journal of the International Society of Sports Nutrition · 2014Article
- The prevalence of exercise-associated hyponatremia in 24-hour ultra-mountain bikers, 24-hour ultra-runners and multi-stage ultra-mountain bikers in the Czech Republic.Journal of the International Society of Sports Nutrition · 2014Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
An increase in body mass due to oedema has been previously described. The aim of this study was to investigate a potential association between both fluid and electrolyte intake and the formation of peripheral oedemas. Fluid and electrolyte intakes and the changes in limb volumes in 50 male 100-km ultra-marathoners were measured. Pre- and post-race serum sodium concentration ([Na(+)]), serum aldosterone concentration, serum copeptin concentration, serum and urine osmolality and body mass were determined. Fluid intake, renal function parameters and urinary output, as well as the changes of volume in the extremities, were measured. The changes of volume in the limbs were measured using plethysmography. Serum [Na(+)] increased by 1.6%; body mass decreased by 1.9 kg. Serum copeptin and aldosterone concentrations were increased. The change in serum copeptin concentration and the change in serum [Na(+)] correlated positively; the change in serum [Na(+)] and body mass correlated negatively. A mean fluid intake of 0.58 L/h was positively related to running speed and negatively to post-race serum [Na(+)]. Total fluid intake was positively related to the changes in both arm and lower leg volumes. Running speed was positively associated with the changes in arm and lower leg volumes; race time was related to the changes in serum copeptin or aldosterone concentrations. To conclude, fluid intake was related to the changes in limb volumes, where athletes with an increased fluid intake developed an increase in limb volumes.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.