Trial reportImmunologic research2011
Immunologically restricted patients exhibit a pronounced inflammation and inadequate response to hypoxia in fracture hematomas.
Trial report in Immunologic research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 36 citations in OpenAlex.
- Atrophic Long-Bone Non-Union: Current Insights into Pathogenesis and Management-A Narrative Review.Journal of clinical medicine · 2026Review
- Infected haematoma in non-immuno-compromised patients following conservatively managed glenohumeral fractures - case reports.Shoulder & elbow · 2023Article
- Elucidating osseointegration in vivo in 3D printed scaffolds eliciting different foreign body responses.Materials today. Bio · 2023Article
- Single-cell RNAseq provides insight into altered immune cell populations in human fracture nonunions.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2023Article
- Impact of Sulfated Hyaluronan on Bone Metabolism in Diabetic Charcot Neuroarthropathy and Degenerative Arthritis.International journal of molecular sciences · 2022Article
- Local immune cell contributions to fracture healing in aged individuals - A novel role for interleukin 22.Experimental & molecular medicine · 2022Article
- Fracture biomechanics influence local and systemic immune responses in a murine fracture-related infection model.Biology open · 2021Article
- Bone Marrow Multipotent Mesenchymal Stromal Cells as Autologous Therapy for Osteonecrosis: Effects of Age and Underlying Causes.Bioengineering (Basel, Switzerland) · 2021Review
- Dynamics of Early Signalling Events during Fracture Healing and Potential Serum Biomarkers of Fracture Non-Union in Humans.Journal of clinical medicine · 2020Article
- Impact of Janus Kinase Inhibition with Tofacitinib on Fundamental Processes of Bone Healing.International journal of molecular sciences · 2020Article
- Defective Proliferation and Osteogenic Potential with Altered Immunoregulatory phenotype of Native Bone marrow-Multipotential Stromal Cells in Atrophic Fracture Non-Union.Scientific reports · 2019Article
- Experience in the Adaptive Immunity Impacts Bone Homeostasis, Remodeling, and Healing.Frontiers in immunology · 2019Article
- CTLA-4 Mediates Inhibitory Function of Mesenchymal Stem/Stromal Cells.International journal of molecular sciences · 2018Article
- The haematoma and its role in bone healing.Journal of experimental orthopaedics · 2017Review
- A Pronounced Inflammatory Activity Characterizes the Early Fracture Healing Phase in Immunologically Restricted Patients.International journal of molecular sciences · 2017Article
- Immunological characterization of the early human fracture hematoma.Immunologic research · 2016Article
- Hypoxia-inducible factor-1α antagonizes the hypoxia-mediated osteoblast cell viability reduction by inhibiting apoptosis.Experimental and therapeutic medicine · 2015Article
- Human immune cells' behavior and survival under bioenergetically restricted conditions in an in vitro fracture hematoma model.Cellular & molecular immunology · 2013Article
- Immunoregulation of bone remodelling.International journal of critical illness and injury science · 2012Article
- Article
Corrections and comments
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Authors and funding
17 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
For patients who are known to have an impaired immune system, bone healing is often impaired. Therefore, it has been suggested that an effectively functioning immune system will have an influence on the quality of bone healing. Here, we demonstrate that cells within the fracture hematoma of immunologically restricted patients (1) exhibit a disturbed osteogenic differentiation (normal SPP1 but diminished RUNX2 expression), (2) show a strong inflammatory reaction (high IL8 and CXCR4), and (3) react on local hypoxia (high expression of HIF1A) but with inadequate target gene responses (diminished LDHA and PGK1 expression). Thus, it is already within the early inflammatory phase of fracture healing that the local gene expression in fracture hematomas of immunologically restricted patients points toward a critical regeneration.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.