Evidence map›Paper›PMID 21720806›Full record

ReviewJournal of neuro-oncology2011

The roles of viruses in brain tumor initiation and oncomodulation.

Alexander Kofman, Lucasz Marcinkiewicz, Evan Dupart, Anton Lyshchev, Boris Martynov, Anatolii Ryndin, Elena Kotelevskaya, Jay Brown, David Schiff, Roger Abounader

Abstract readReview
In one paragraph

Review in Journal of neuro-oncology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 60 citations in OpenAlex.

  1. Trial
  2. Article
  3. Epstein-Barr Virus in Brain Cancer-Friend or Foe?International journal of molecular sciences · 2026
    Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Low Prevalence of HSV-1 andDiagnostics (Basel, Switzerland) · 2023
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Review
  17. Review
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Alexander KofmanDepartment of Microbiology, University of Virginia, P.O. Box 800168, Charlottesville, VA 22908, USA.
Lucasz Marcinkiewicz
Evan Dupart
Anton Lyshchev
Boris Martynov
Anatolii Ryndin
Elena Kotelevskaya
Jay Brown
David Schiff
Roger Abounader
University of Virginia · USConsultative and Diagnostic Center · RUS. M. Kirov Military Medical Academy · RU

Funding

Receptor Tyrosine Kinase/PTEN Interactions in GliomasR01NS045209 · NINDS · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI ABOUNADER, ROGER · 2003 to 2017
$4.1M
Molecular interactions and restoration strategies of PTEN and p53 in gliomasR01CA134843 · NCI · UNIVERSITY OF VIRGINIA · PI ABOUNADER, ROGER · 2010 to 2014
$1.5M
NCI NIH HHS R01 CA134843NINDS NIH HHS R01 NS045209
6 · The paper itself

Abstract

While some avian retroviruses have been shown to induce gliomas in animal models, human herpesviruses, specifically, the most extensively studied cytomegalovirus, and the much less studied roseolovirus HHV-6, and Herpes simplex viruses 1 and 2, currently attract more and more attention as possible contributing or initiating factors in the development of human brain tumors. The aim of this review is to summarize and highlight the most provoking findings indicating a potential causative link between brain tumors, specifically malignant gliomas, and viruses in the context of the concepts of viral oncomodulation and the tumor stem cell origin.

Indexed as

AnimalsBrain NeoplasmsCell Transformation, ViralHumansNeoplastic Stem CellsRetroviridaeTumor Virus Infections

Identifiers

PMID21720806
PMCPMC3278219
OpenAlexW1974737166

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.