ArticlePloS one2011
Prevalence of metabolic syndrome and risks of abnormal serum alanine aminotransferase in Hispanics: a population-based study.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
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The trial behind it
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- Prevalence of metabolic syndrome in Mainland China: a meta-analysis of published studies.BMC public health · 2016Pooled it
- PNPLA3 polymorphisms and liver aminotransferase levels in a Mexican American population.Clinical and investigative medicine. Medecine clinique et experimentale · 2012Trial
- Prevalence and determinants of metabolic syndrome among women in Chinese rural areas.PloS one · 2012Trial
- Gut phageome in Mexican Americans: a population at high risk for metabolic dysfunction-associated steatotic liver disease and diabetes.mSystems · 2024Article
- Prevalence and metabolic determinants of abnormal alanine aminotransferase: A cross-sectional study of Iranian adults, 2018-2022.Journal of clinical laboratory analysis · 2023Article
- Criterion Validity of a Short Food Frequency Questionnaire for Mexican American Adults.Nutrients · 2022Article
- Gut Microbiome Alterations Associated with Diabetes in Mexican Americans in South Texas.mSystems · 2022Article
- Factors associated with elevated alanine aminotransferase in employees of a German chemical company: results of a large cross-sectional study.BMC gastroenterology · 2021Article
- Magnitude, components and predictors of metabolic syndrome in Northern Ethiopia: Evidences from regional NCDs STEPS survey, 2016.PloS one · 2021Article
- Metabolic Risk and Depression among Elderly Mexican Americans: The Roles of Nativity Status.Ethnicity & disease · 2021Article
- Risk of metabolic syndrome in participants within the normal range of alanine aminotransferase: A population-based nationwide study.PloS one · 2020Article
- Association of interleukin-6 polymorphisms with obesity or metabolic traits in young Mexican-Americans.Obesity science & practice · 2018Article
- Burden of hepatocellular carcinoma among hispanics in South Texas: a systematic review.Biomarker research · 2017Review
- The Precarious Health of Young Mexican American Men in South Texas, Cameron County Hispanic Cohort, 2004-2015.Preventing chronic disease · 2016Article
- Longitudinal association of obesity, metabolic syndrome and diabetes with risk of elevated aminotransferase levels in a cohort of Mexican health workers.Journal of digestive diseases · 2016Article
- Liver and Other Gastrointestinal Cancers Are Frequent in Mexican Americans.Journal of racial and ethnic health disparities · 2016Article
- Cirrhosis and Advanced Fibrosis in Hispanics in Texas: The Dominant Contribution of Central Obesity.PloS one · 2016Article
- Hepatitis C virus in Mexican Americans: a population-based study reveals relatively high prevalence and negative association with diabetes.Epidemiology and infection · 2016Article
- Genetic analysis of nonalcoholic fatty liver disease within a Caribbean-Hispanic population.Molecular genetics & genomic medicine · 2015Article
- Depression, obesity, and metabolic syndrome: prevalence and risks of comorbidity in a population-based representative sample of Mexican Americans.The Journal of clinical psychiatry · 2015Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
aimStudy the prevalence of metabolic syndrome (MS) and risk factors for and association with elevated alanine aminotransferase (ALT) as markers of hepatic injury in a large Hispanic health disparity cohort with high rates of obesity.
methodsAnalysis of data from a prospective cross-sectional population based study. From 2004-7, we randomly recruited 2000 community participants to the Cameron County Hispanic Cohort collecting extensive socioeconomic, clinical and laboratory data. We excluded 153 subjects due to critical missing data. Pearson chi-square tests and Student's t-tests were used for categorical and continuous variable analysis, respectively. Logistic regression analysis was performed to determine the risk factors for elevated ALT.
resultsThe mean age of the cohort was 45 years and 67% were females. The majority of the cohort was either overweight (32.4%) or obese (50.7%). Almost half (43.7%) had MS and nearly one-third diabetes. Elevated ALT level was more prevalent in males than females. Obesity was a strong risk for abnormal ALT in both genders. Hypertriglyceridemia, hypercholesterolemia and young age were risks for elevated ALT in males only, whereas increased fasting plasma glucose was associated with elevated ALT in females only.
conclusionWe identified high prevalence of MS and markers of liver injury in this large Mexican American cohort with gender differences in prevalence and risk factors, with younger males at greatest risk.
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