ArticleFrontiers in physiology2011
Toward a multi-scale computational model of arterial adaptation in hypertension: verification of a multi-cell agent based model.
Article in Frontiers in physiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 52 citations in OpenAlex.
- Bridging hemodynamics, tissue mechanics, and pathophysiology in coronary artery disease: A new agent-based model with tetrahedral mesh integration.Journal of biomechanics · 2025Article
- Survey and perspective on verification, validation, and uncertainty quantification of digital twins for precision medicine.NPJ digital medicine · 2025Review
- A perfectly imperfect engine: Utilizing the digital twin paradigm in pulmonary hypertension.Pulmonary circulation · 2024Review
- Agent-based model provides insight into the mechanisms behind failed regeneration following volumetric muscle loss injury.PLoS computational biology · 2021Article
- Multiscale Modeling of Vascular Remodeling Induced by Wall Shear Stress.Frontiers in physiology · 2021Article
- [Review of studies on the biomechanical modelling of the coupling effect between stent degradation and blood vessel remodeling].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2020Article
- Notch in mechanotransduction - from molecular mechanosensitivity to tissue mechanostasis.Journal of cell science · 2020Review
- Lateral induction limits the impact of cell connectivity on Notch signaling in arterial walls.International journal for numerical methods in biomedical engineering · 2020Article
- Agent-based model illustrates the role of the microenvironment in regeneration in healthy and mdx skeletal muscle.Journal of applied physiology (Bethesda, Md. : 1985) · 2018Article
- Mechanosensitivity of Jagged-Notch signaling can induce a switch-type behavior in vascular homeostasis.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Mechanobiological model of arterial growth and remodeling.Biomechanics and modeling in mechanobiology · 2018Article
- Agent-based computational model of retinal angiogenesis simulates microvascular network morphology as a function of pericyte coverage.Microcirculation (New York, N.Y. : 1994) · 2017Article
- An agent-based model of leukocyte transendothelial migration during atherogenesis.PLoS computational biology · 2017Article
- Prior Distributions of Material Parameters for Bayesian Calibration of Growth and Remodeling Computational Model of Abdominal Aortic Wall.Journal of biomechanical engineering · 2015Article
- Investigating biocomplexity through the agent-based paradigm.Briefings in bioinformatics · 2015Review
- Multiscale computational models of complex biological systems.Annual review of biomedical engineering · 2013Review
- Article
- Extracellular matrix and the mechanics of large artery development.Biomechanics and modeling in mechanobiology · 2012Article
- Integration of experimental and computational approaches to sprouting angiogenesis.Current opinion in hematology · 2012Review
- Modelling the lymphatic system: challenges and opportunities.Journal of the Royal Society, Interface · 2012Review
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
Agent-based models (ABMs) represent a novel approach to study and simulate complex mechano chemo-biological responses at the cellular level. Such models have been used to simulate a variety of emergent responses in the vasculature, including angiogenesis and vasculogenesis. Although not used previously to study large vessel adaptations, we submit that ABMs will prove equally useful in such studies when combined with well-established continuum models to form multi-scale models of tissue-level phenomena. In order to couple agent-based and continuum models, however, there is a need to ensure that each model faithfully represents the best data available at the relevant scale and that there is consistency between models under baseline conditions. Toward this end, we describe the development and verification of an ABM of endothelial and smooth muscle cell responses to mechanical stimuli in a large artery. A refined rule-set is proposed based on a broad literature search, a new scoring system for assigning confidence in the rules, and a parameter sensitivity study. To illustrate the utility of these new methods for rule selection, as well as the consistency achieved with continuum-level models, we simulate the behavior of a mouse aorta during homeostasis and in response to both transient and sustained increases in pressure. The simulated responses depend on the altered cellular production of seven key mitogenic, synthetic, and proteolytic biomolecules, which in turn control the turnover of intramural cells and extracellular matrix. These events are responsible for gross changes in vessel wall morphology. This new ABM is shown to be appropriately stable under homeostatic conditions, insensitive to transient elevations in blood pressure, and responsive to increased intramural wall stress in hypertension.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.