ArticleInternational journal of nanomedicine2011
Ethylenediamine functionalized-single-walled nanotube (f-SWNT)-assisted in vitro delivery of the oncogene suppressor p53 gene to breast cancer MCF-7 cells.
Article in International journal of nanomedicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 77 citations in OpenAlex.
- Anti-CD133-grafted single-walled carbon nanotubes as doxorubicin carrier.Biological procedures online · 2025Article
- Review
- Discovery of Drugs Targeting Mutant p53 and Progress in Nano-Enabled Therapeutic Strategy for p53-Mutated Cancers.Biomolecules · 2025Review
- Biochemical Nanotubes Containing Heterocycles as Artificial Strands for Pseudo Duplex and Triplex DNA Formation.The journal of physical chemistry. B · 2025Article
- Advancements inMolecules (Basel, Switzerland) · 2024Review
- Carbon-Based Nanostructures as Emerging Materials for Gene Delivery Applications.Pharmaceutics · 2024Review
- Nanotechnological advances in cancer: therapy a comprehensive review of carbon nanotube applications.Frontiers in bioengineering and biotechnology · 2024Review
- Eco-friendly synthesis of carbon nanotubes and their cancer theranostic applications.Materials advances · 2022Review
- Clinical updates on tyrosine kinase inhibitors in HER2-positive breast cancer.Frontiers in pharmacology · 2022Review
- Insights on functionalized carbon nanotubes for cancer theranostics.Journal of nanobiotechnology · 2021Review
- Nanobiolistics: An Emerging Genetic Transformation Approach.Methods in molecular biology (Clifton, N.J.) · 2020Article
- Enhanced Gene Delivery in Bacterial and Mammalian Cells Using PEGylated Calcium Doped Magnetic Nanograin.International journal of nanomedicine · 2019Article
- Epoxidation of Carbon Nanocapsules: Decoration of Single-Walled Carbon Nanotubes Filled with Metal Halides.Nanomaterials (Basel, Switzerland) · 2018Article
- Inhibition of cell proliferation and migration through nucleobase-modified polyamidoamine-mediated p53 delivery.International journal of nanomedicine · 2018Article
- Applications of Functionalized Carbon Nanotubes for the Therapy and Diagnosis of Cancer.Polymers · 2017Review
- Nanomedicine applications in the treatment of breast cancer: current state of the art.International journal of nanomedicine · 2017Review
- A review on current nanomaterials and their drug conjugate for targeted breast cancer treatment.International journal of nanomedicine · 2017Review
- Synthesis of double-clickable functionalised graphene oxide for biological applications.Chemical communications (Cambridge, England) · 2015Article
- Carbon nanotubes part II: a remarkable carrier for drug and gene delivery.Expert opinion on drug delivery · 2015Review
- Nanodelivery of Parthenolide Using Functionalized Nanographene Enhances its Anticancer Activity.RSC advances · 2015Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
Abstract
A gene delivery concept based on ethylenediamine-functionalized single-walled carbon nanotubes (f-SWCNTs) using the oncogene suppressor p53 gene as a model gene was successfully tested in vitro in MCF-7 breast cancer cells. The f-SWCNTs-p53 complexes were introduced into the cell medium at a concentration of 20 μg mL(-1) and cells were exposed for 24, 48, and 72 hours. Standard ethidium bromide and acridine orange assays were used to detect apoptotic cells and indicated that a significantly larger percentage of the cells (approx 40%) were dead after 72 hours of exposure to f-SWCNTs-p53 as compared to the control cells, which were exposed to only p53 or f-SWCNTs, respectively. To further support the uptake and expression of the genes within the cells, green fluorescent protein-tagged p53, attached to the f-SWCNTs was added to the medium and the complex was observed to be strongly expressed in the cells. Moreover, caspase 3 activity was found to be highly enhanced in cells incubated with the f-SWCNTs-p53 complex, indicating strongly induced apoptosis. This system could be the foundation for novel gene delivery platforms based on the unique structural and morphological properties of multi-functional nanomaterials.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.