ArticleInternational journal of nanomedicine2011
A study on the preparation and characterization of plasmid DNA and drug-containing magnetic nanoliposomes for the treatment of tumors.
Article in International journal of nanomedicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed.
- Biomimetic Magnetic Nanovesicles ("Magnetic Liposomes"): Current Synthesis Approaches and Biomedical Applications.Mini reviews in medicinal chemistry · 2025Review
- Evaluation of Iron Oxide Nanoparticles Toxicity on Liver Cells of BALB/c Rats.Iranian Red Crescent medical journal · 2016Article
- Study of the combined treatment of lung cancer using gene-loaded immunomagnetic albumin nanospheres in vitro and in vivo.International journal of nanomedicine · 2016Article
- Experimental treatment of breast cancer-bearing BALB/c mice by artemisinin and transferrin-loaded magnetic nanoliposomes.Pharmacognosy magazine · 2015Article
- The study on the preparation and characterization of gene-loaded immunomagnetic albumin nanospheres and their anti-cell proliferative effect combined with magnetic fluid hyperthermia on GLC-82 cells.Drug design, development and therapy · 2015Article
- Preparation, characterization and in vitro efficacy of magnetic nanoliposomes containing the artemisinin and transferrin.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2014Article
- Targeted hyperthermia after selective embolization with ferromagnetic nanoparticles in a VX2 rabbit liver tumor model.International journal of nanomedicine · 2013Article
- Article
- Influence of charge on FITC-BSA-loaded chondroitin sulfate-chitosan nanoparticles upon cell uptake in human Caco-2 cell monolayers.International journal of nanomedicine · 2012Article
- The comparison of protein-entrapped liposomes and lipoparticles: preparation, characterization, and efficacy of cellular uptake.International journal of nanomedicine · 2011Article
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5 authors.
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Abstract
purposeTo explore the preparation and characterization of a novel nanosized magnetic liposome containing the PEI-As(2)O(3)/Mn(0.5)Zn(0.5)Fe(2)O(4) complex.
methodsMn(0.5)Zn(0.5)Fe(2)O(4) and As(2)O(3)/Mn(0.5)Zn(0.5)Fe(2)O(4) nanoparticles were prepared by chemical coprecipitation and loaded with PEI. The PEI- As(2)O(3)/Mn(0.5)Zn(0.5)Fe(2)O(4) complex was characterized using transmission electron and scanning electron microscopy, X-ray diffraction, energy dispersive spectrometry, and Fourier transform infrared spectroscopy. Cell transfection experiments were performed to evaluate the transfect efficiency. Magnetic nanoliposomes were prepared by rotatory evaporation and their shape, diameter, and thermodynamic characteristics were observed.
resultsMn(0.5)Zn(0.5)Fe(2)O(4) and PEI-As(2)O(3)/Mn(0.5)Zn(0.5)Fe(2)O(4) nanoparticles were spherical, with an average diameter of 20-40 nm. PEI-As(2)O(3)/Mn(0.5)Zn(0.5)Fe(2)O(4) was an appropriate carrier for the delivery of a foreign gene to HepG2 cells. Energy dispersive spectrometry results confirmed the presence of the elements nitrogen and arsenic. Nanoliposomes of approximately 100 nm were observed under a transmission electron microscope. Upon exposure to an alternating magnetic field, they also had good magnetic responsiveness, even though Mn(0.5)Zn(0.5)Fe(2)O(4)was modified by PEI and encased in liposomes. Temperatures increased to 37°C-54°C depending on different concentrations of PEI-As(2)O(3)/Mn(0.5)Zn(0.5)Fe(2)O(4)and remained stable thereafter.
conclusionOur results suggest that PEI-As(2)O(3)/Mn(0.5)Zn(0.5)Fe(2)O(4) magnetic nanoliposomes are an excellent biomaterial, which has multiple benefits in tumor thermotherapy, gene therapy, and chemotherapy.
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