ReviewCaries research2011
Antimicrobial traits of tea- and cranberry-derived polyphenols against Streptococcus mutans.
Review in Caries research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Antibacterial and Antimicrobial Effects of Xanthorrhizol in the Prevention of Dental Caries: A Systematic Review.Drug design, development and therapy · 2021Pooled it
- Comparative evaluation of cranberry extract and sodium fluoride as mouth rinses on S. mutans counts in children: a double-blind randomized controlled trial.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2024Trial
- The anticaries effect of a food extract (shiitake) in a short-term clinical study.Journal of biomedicine & biotechnology · 2012Trial
- Classification and Anti-Pathogens (Basel, Switzerland) · 2026Review
- Assessment of the Relationship between Periodontitis and Cardiac Parameters in Patients with Early Chronic Heart Failure: A Cross-Sectional Study.Journal of functional morphology and kinesiology · 2024Article
- Sports Diet and Oral Health in Athletes: A Comprehensive Review.Medicina (Kaunas, Lithuania) · 2024Review
- The Evolving Microbiome of Dental Caries.Microorganisms · 2024Review
- Potential of Selected African Medicinal Plants as Alternative Therapeutics against Multi-Drug-Resistant Bacteria.Biomedicines · 2023Review
- The Role of Natural Compounds in Optimizing Contemporary Dental Treatment-Current Status and Future Trends.Journal of functional biomaterials · 2023Review
- Antioxidant Materials in Oral and Maxillofacial Tissue Regeneration: A Narrative Review of the Literature.Antioxidants (Basel, Switzerland) · 2023Review
- Evaluation of farnesol orally and topically against experimental cutaneous leishmaniasis: In -vivo analysis.PloS one · 2023Article
- Antiparasitic effect of Farnesol against Leishmania major: A rationale from in vitro and in silico investigations.PloS one · 2023Article
- Physicochemical and microbiological assessment of a dental adhesive doped with cashew nut shell liquid.Odontology · 2022Article
- The antimicrobial effect of Rosmarinus officinalis extracts on oral initial adhesion ex vivo.Clinical oral investigations · 2022Article
- Procyanidins and Their Therapeutic Potential against Oral Diseases.Molecules (Basel, Switzerland) · 2022Review
- Oolong Tea Consumption and the Risk of Oral Squamous Cell Carcinoma: A Propensity Score-Based Analysis in Southeast China.Frontiers in nutrition · 2022Article
- Effect of LongZhang Gargle on Dual-Species Biofilm of Candida albicans and Streptococcus mutans.BioMed research international · 2021Article
- Growth Inhibitory Effects of Antimicrobial Natural Products against Cariogenic and Health-Associated Oral Bacterial Species.Oral health & preventive dentistry · 2020Article
- Potential Allylpyrocatechol Derivatives as Antibacterial Agent Against Oral Pathogen ofDrug design, development and therapy · 2020Article
- TargetingMedChemComm · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
There are over 750 species of bacteria that inhabit the human oral cavity, but only a small fraction of those are attributed to causing plaque-related diseases such as caries. Streptococcus mutans is accepted as the main cariogenic agent and there is substantial knowledge regarding the specific virulence factors that render the organism a pathogen. There has been rising interest in alternative, target-specific treatment options as opposed to nonspecific mechanical plaque removal or application of broad-spectrum antibacterials that are currently in use. The impact of diet on oral health is undeniable, and this is directly observable in populations that consume high quantities of polyphenol-rich foods or beverages. Such populations have low caries incidence and better overall oral health. Camellia sinensis, the plant from which various forms of tea are derived, and Vaccinium macrocarpon (American cranberry fruit) have received notable attention both for their prevalence in the human diet as well as for their unique composition of polyphenols. The biologically active constituents of these plants have demonstrated potent enzyme-inhibitory properties without being bactericidal, a key quality that is important in developing therapies that will not cause microorganisms to develop resistance. The aim of this review is to consider studies that have investigated the feasibility of tea, cranberry, and other select plant derivatives as a potential basis for alternative therapeutic agents against Streptococcus mutans and to evaluate their current and future clinical relevance.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.