ArticleSexual development : genetics, molecular biology, evolution, endocrinology, embryology, and pathology of sex determination and differentiation2011
Dimorphic expression of various transcription factor and steroidogenic enzyme genes during gonadal ontogeny in the air-breathing catfish, Clarias gariepinus.
Article in Sexual development : genetics, molecular biology, evolution, endocrinology, embryology, and pathology of sex determination and differentiation, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 82 citations in OpenAlex.
- Molecular Mechanisms of Gonadal Differentiation Induced by 17β-Estradiol and Testosterone Propionate inAnimals : an open access journal from MDPI · 2026Article
- Production of YY super-males in Pseudobagrus ussuriensis using estradiol-induced XY pseudo-females.Fish physiology and biochemistry · 2026Article
- Evaluation of season and sex specific differential gonadal transcriptomics in Himalayan snow trout Schizothorax plagiostomus, Heckel, 1838.Scientific reports · 2026Article
- De Novo Assembly, Characterization and Comparative Transcriptome Analysis of the Gonads of Jade Perch (Animals : an open access journal from MDPI · 2023Article
- Comparison of differential expression genes in ovaries and testes of Pearlscale angelfish Centropyge vrolikii based on RNA-Seq analysis.Fish physiology and biochemistry · 2021Article
- Identification of reproduction-related genes and pathways in the Culter alburnus H-P-G axis and characterization of their expression differences in malformed and normal gynogenetic ovaries.Fish physiology and biochemistry · 2021Article
- Steroidogenesis and its regulation in teleost-a review.Fish physiology and biochemistry · 2020Review
- Comparative transcriptome analysis of male and female gonads reveals sex-biased genes in spotted scat (Scatophagus argus).Fish physiology and biochemistry · 2019Article
- Dimorphic expression of sex-related genes in different gonadal development stages of sterlet, Acipenser ruthenus, a primitive fish species.Fish physiology and biochemistry · 2017Article
- Transcriptome analysis of the gonads of olive flounder (Paralichthys olivaceus).Fish physiology and biochemistry · 2016Article
- Molecular identification and expression of the Foxl2 gene during gonadal sex differentiation in northern snakehead Channa argus.Fish physiology and biochemistry · 2015Article
- Sex determination in annual fishes: Searching for the master sex-determining gene in Austrolebias charrua (Cyprinodontiformes, Rivulidae).Genetics and molecular biology · 2014Article
- Cloning and expression analysis of Foxl2 during the reproductive cycle in Korean rockfish, Sebastes schlegeli.Fish physiology and biochemistry · 2013Article
- Expression of dmrt1 and sox9 during gonadal development in the Siberian sturgeon (Acipenser baerii).Fish physiology and biochemistry · 2013Article
- Male-biased genes in catfish as revealed by RNA-Seq analysis of the testis transcriptome.PloS one · 2013Article
- Dmrt genes in the development and evolution of sexual dimorphism.Trends in genetics : TIG · 2012Review
- Molecular cloning and expression analysis of fushi tarazu factor 1 in the brain of air-breathing catfish, Clarias gariepinus.PloS one · 2011Article
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8 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
In the present study the expression of 13 genes known to be involved in sex differentiation and steroidogenesis in catfish was analyzed during gonadal ontogeny by quantitative real-time RT-PCR. Dmrt1 and sox9a showed exclusive expression in male gonads while ovarian aromatase (cyp19a1) and foxl2 were abundant in differentiating female gonads. Most of the genes related to steroidogenesis were expressed only after gonadal differentiation. However, genes coding for 3β-hydroxysteroid dehydrogenase (3β-hsd), 17α-hydroxylase/C17-20 lyase type 1 (cyp17) and steroidogenic acute regulatory protein (star) were barely detectable during gonadal differentiation. Ovarian aromatase, cyp19a1, which is responsible for estradiol-17β biosynthesis in females, was expressed very early in the undifferentiated gonads of catfish, around 30-40 days post hatch (dph). The steroidogenic enzyme, 11β-hydroxylase (cyp11b1) required for the production of 11-ketotestosterone (11-KT) was expressed only after differentiation of testis. These results suggest that estradiol-17β has a critical role in ovarian differentiation, while the role of 11-KT in testicular differentiation is doubtful. In conclusion, dimorphic expression of dmrt1 and sox9a in gonads during early development is required for testicular differentiation, and sex-specific expression of cyp19a1 and foxl2 in females plays a critical role in ovarian development. Our study reveals that the critical period of gonadal differentiation in catfish starts around 30-40 dph when sex-specific genes showed differential expression.
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