Evidence map›Paper›PMID 21719917›Full record

ArticleEuropean journal of mass spectrometry (Chichester, England)2011

Negative electron transfer dissociation Fourier transform mass spectrometry of glycosaminoglycan carbohydrates.

Franklin E Leach, Jeremy J Wolff, Zhongping Xiao, Melissa Ly, Tatiana N Laremore, Sailaja Arungundram, Kanar Al-Mafraji, Andre Venot, Geert-Jan Boons, Robert J Linhardt and 1 more

Abstract read
In one paragraph

Article in European journal of mass spectrometry (Chichester, England), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 43 citations in OpenAlex.

  1. Glycan Sequencing, A Brief Primer.Glycoscience & therapy · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 2 countries.

Franklin E LeachDepartment of Chemistry, University of Georgia, Athens, GA 30602, USA.
Jeremy J Wolff
Zhongping Xiao
Melissa Ly
Tatiana N Laremore
Sailaja Arungundram
Kanar Al-Mafraji
Andre Venot
Geert-Jan Boons
Robert J Linhardt
I Jonathan Amster
University of Georgia · USRensselaer Polytechnic Institute · USBruker (United States) · USOcean University of China · CNPennsylvania State University · US

Funding

ZINC DEFICIENCY &PROTEIN EXPRESSION IN RAT OLFACTORY BULBSP41RR005351 · NCRR · UNIVERSITY OF GEORGIA (UGA) · PI VENOT, ANDRE · 1989 to 2011
$18.4M
TR&D3. Approaches to Proteoglycan Function at Biochemical and Cellular LevelsP41GM103390 · NIGMS · UNIVERSITY OF GEORGIA · PI MOREMEN, KELLEY W. · 2012 to 2019
$14.5M
SEQUENCING THE POLYSACCHARIDE COMPONENT OF PROTEOGLYCANSR01GM038060 · NIGMS · UNIVERSITY OF IOWA · PI LINHARDT, ROBERT J · 1988 to 2012
$2.8M
NCRR NIH HHS P41 RR005351NCRR NIH HHS P41RR005351NIGMS NIH HHS 2R01-GM038060-16NIGMS NIH HHS P41 GM103390NIGMS NIH HHS R01 GM038060
6 · The paper itself

Abstract

Electron transfer through gas phase ion-ion reactions has led to the widespread application of electron- based techniques once only capable in ion trapping mass spectrometers. Although any mass analyzer can in theory be coupled to an ion-ion reaction device (typically a 3-D ion trap), some systems of interest exceed the capabilities of most mass spectrometers. This case is particularly true in the structural characterization of glycosaminoglycan (GAG) oligosaccharides. To adequately characterize highly sulfated GAGs or oligosaccharides above the tetrasaccharide level, a high resolution mass analyzer is required. To extend previous efforts on an ion trap mass spectrometer, negative electron transfer dissociation coupled with a Fourier transform ion cyclotron resonance mass spectrometer has been applied to increasingly sulfated heparan sulfate and heparin tetrasaccharides as well as a dermatan sulfate octasaccharide. Results similar to those obtained by electron detachment dissociation are observed.

Indexed as

Fourier AnalysisAnimalsCarbohydrate SequenceDermatan SulfateGlycosaminoglycansHeparan SulfateModels, MolecularMolecular Sequence DataSpectrometry, Mass, Electrospray IonizationSwineDermatan SulfateGlycosaminoglycansHeparan Sulfate

Identifiers

PMID21719917
PMCPMC3347043
OpenAlexW2106538021

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.