ArticleNicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco2011
Menthol preference among smokers: association with TRPA1 variants.
Article in Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 29 citations in OpenAlex.
- Acute effects of inhaled menthol on the rewarding effects of intravenous nicotine in smokers.Journal of psychopharmacology (Oxford, England) · 2018Trial
- Investigating the role of nicotinic acetylcholine receptors in menthol's effects in mice.Drug and alcohol dependence · 2024Article
- Genotypic Differences in the Effects of Menthol on Nicotine Intake and Preference in Mice.Frontiers in neuroscience · 2022Article
- Associations between chronic cigarette smoking and taste function: Results from the 2013-2014 national health and nutrition examination survey.Physiology & behavior · 2021Article
- Interactions between Chemesthesis and Taste: Role of TRPA1 and TRPV1.International journal of molecular sciences · 2021Review
- TRPA1 gene variants hurting our feelings.Pflugers Archiv : European journal of physiology · 2020Review
- Effect of menthol on nicotine intake and relapse vulnerability in a rat model of concurrent intravenous menthol/nicotine self-administration.Psychopharmacology · 2019Article
- An African-specific haplotype in MRGPRX4 is associated with menthol cigarette smoking.PLoS genetics · 2019Article
- Article
- Threshold dose for behavioral discrimination of cigarette nicotine content in menthol vs. non-menthol smokers.Psychopharmacology · 2017Article
- TRPA1 gene polymorphisms and childhood asthma.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2017Article
- Effect of Menthol-preferring Status on Response to Intravenous Nicotine.Tobacco regulatory science · 2016Article
- Menthol tobacco use is correlated with mental health symptoms in a national sample of young adults: implications for future health risks and policy recommendations.Tobacco induced diseases · 2016Article
- Airway hydration and COPD.Cellular and molecular life sciences : CMLS · 2015Review
- Terpenes and lipids of the endocannabinoid and transient-receptor-potential-channel biosignaling systems.ACS chemical neuroscience · 2014Review
- Transient receptor potential channels as targets for phytochemicals.ACS chemical neuroscience · 2014Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
introductionPreference for smoking menthol cigarettes differs from individual to individual and population to population in ways that may provide higher levels of nicotine intake and contribute to smoking's morbidity and mortality. Menthol acts at sites that include the transient receptor potential (TRP) A1 channel that is expressed by nociceptors in the lung and airways, suggesting that individual and population differences in TRPA1 sequences might contribute to observed differences in menthol preference among smokers.
methodsWe have thus sought association between menthol preference and common variants in the TRPA1 gene in heavier and lighter European-American smokers. Smokers were recruited for studies of smoking cessation in North Carolina and of substance abuse genetics in Maryland.
resultsA common TRPA1 haplotype is defined by 1 missense and 10 intronic single nucleotide polymorphisms that display significant (.006 < p < .05; χ(2)) association with preference for mentholated cigarettes in heavy smokers (odds ratio ca. 1.3). There are smaller trends in the same direction in lighter smokers.
conclusionsThis TRPA1 haplotype provides a novel biological basis for individual differences in menthol preference and possibly for actions of other agents that act at TRPA1.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.