ArticleStroke2011
Vitamin D deficiency is associated with subclinical carotid atherosclerosis: the Northern Manhattan study.
Article in Stroke, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed, 101 citations in OpenAlex.
- Trial
- Elevated homocysteine and carotid plaque area and densitometry in the Northern Manhattan Study.Stroke · 2013Trial
- Vitamin D Supplementation and Its Effects on Blood Glucose, Serum Lipid Profile, Blood Pressure, and Carotid Tunica Intima-Media Thickness in Healthy Adult Male Dogs.Veterinary medicine and science · 2026Article
- Circulating vitamin D and follicle-stimulating hormone levels are associated with subclinical atherosclerosis in climacteric women with menopausal syndrome.Frontiers in endocrinology · 2026Article
- Vitamin D Deficiency as an Independent Predictor for Plaque Vulnerability and All-Cause Mortality in Patients with High-Grade Carotid Disease.Journal of clinical medicine · 2025Article
- Association of serum calcium, vitamin D, and C-reactive protein with all-cause and cause-specific mortality in an osteoarthritis population in the UK: a prospective cohort study.BMC public health · 2024Observational
- Associations of genetically predicted vitamin D status and deficiency with the risk of carotid artery plaque: a Mendelian randomization study.Scientific reports · 2024Article
- Ultrasound Assessment of Carotid Intima-Media Thickness: Comparison between Diabetes and Nondiabetes Subjects, and Correlation with Serum Vitamin D.Radiology research and practice · 2024Article
- Inflammation and endothelial function relevant genetic polymorphisms, carotid atherosclerosis, and vascular events in high-risk stroke population.Frontiers in neurology · 2024Article
- Article
- Role of Vitamin D Deficiency in the Pathogenesis of Cardiovascular and Cerebrovascular Diseases.Nutrients · 2023Review
- Variants in genes related to inflammation and endothelial function can increase the risk for carotid atherosclerosis in southwestern China.Frontiers in neurology · 2023Article
- The P2RY12 receptor promotes VSMC-derived foam cell formation by inhibiting autophagy in advanced atherosclerosis.Autophagy · 2021Article
- Development and Validation of 3-Month Major Post-Stroke Depression Prediction Nomogram After Acute Ischemic Stroke Onset.Clinical interventions in aging · 2021Article
- Atherosclerosis in SLE: a potential role for serum parathormone levels.Lupus science & medicine · 2020Article
- The unique association between the level of peripheral blood monocytes and the prevalence of diabetic retinopathy: a cross-sectional study.Journal of translational medicine · 2020Article
- The association between serum 25-hydroxyvitamin D level and subclinical atherosclerosis in healthy population.Current journal of neurology · 2020Article
- Role of Vitamin D in the Outcome of Ischemic Stroke- A Randomized Controlled Trial.Journal of clinical and diagnostic research : JCDR · 2017Article
- Diagnostic performance of bone metabolic indexes for the detection of stroke.Saudi medical journal · 2017Article
- Calcium Phosphate Product Is Associated with Subclinical Carotid Atherosclerosis in Type 2 Diabetes.Journal of diabetes research · 2017Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
background and purposeThe purpose of this study was to assess the association of vitamin D deficiency and indices of mineral metabolism with subclinical carotid markers that predict cardiovascular events.
methodsTwo hundred three community-dwelling adults (Northern Manhattan Study; age, 68 ± 11; age range, 50 to 93 years) had serum measurements (calcium, phosphorus, 25-hydroxyvitamin D, 1,25-dihydroxyvitamin D, parathyroid hormone) and carotid ultrasound (plaque presence, number, maximal carotid plaque thickness, intima-media thickness).
resultsAdjusting for cardiovascular risk factors, plaque number was associated with phosphorus levels (β=0.39 per 1-mg/dL increase; P=0.02) and calcium-phosphorus product (β=0.36 per 10-U increase; P=0.03). In those with plaque (N=116 [57%]), the association of plaque number with phosphorus and calcium-phosphorus product persisted. In addition, 25-hydroxyvitamin D was inversely associated with both intima-media thickness (β=-0.01 per 10-ng/mL increase; P=0.05) and maximal carotid plaque thickness (β=-0.10 per 10-ng/mL increase; P=0.03). In a model containing traditional cardiac risk factors and indices of mineral metabolism, 25-hydroxyvitamin D accounted for 13% of the variance in both intima-media thickness and maximal carotid plaque thickness. Calcium, parathyroid hormone, and 1,25-dihydroxyvitamin D levels were not associated with carotid measures.
conclusionsAfter adjusting for cardiovascular risk factors and renal function, serum phosphorus and calcium-phosphorus product were associated with a greater burden of subclinical carotid atherosclerosis. Low 25-hydroxyvitamin D levels were associated with increased intima-media thickness and maximal carotid plaque thickness in those with plaque, and 25-hydroxyvitamin D contributed in a robust manner to the variance in both. These results confirm and extend data on the association of low vitamin D levels with subclinical carotid atherosclerosis. The precise nature of this association and the optimum levels of vitamin D for vascular health remain to be elucidated.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.