ArticleArteriosclerosis, thrombosis, and vascular biology2011
Plasminogen regulates stromal cell-derived factor-1/CXCR4-mediated hematopoietic stem cell mobilization by activation of matrix metalloproteinase-9.
Article in Arteriosclerosis, thrombosis, and vascular biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 28 citations in OpenAlex.
- Bioactive materials forBioactive materials · 2024Review
- Optimization of an Intranasal Route for the Delivery of Human Neural Stem Cells to Treat a Neonatal Hypoxic-Ischemic Brain Injury Rat Model.Neuropsychiatric disease and treatment · 2022Article
- Parallel Murine and Human Plaque Proteomics Reveals Pathways of Plaque Rupture.Circulation research · 2020Article
- Roles of fibrinolytic factors in the alterations in bone marrow hematopoietic stem/progenitor cells during bone repair.Inflammation and regeneration · 2020Review
- Review
- The impact of hypoxic-ischemic brain injury on stem cell mobilization, migration, adhesion, and proliferation.Neural regeneration research · 2018Review
- Roles of plasminogen in the alterations in bone marrow hematopoietic stem cells during bone repair.Bone reports · 2018Article
- TGF-β-induced intracellular PAI-1 is responsible for retaining hematopoietic stem cells in the niche.Blood · 2017Article
- Neutrophil gelatinase associated lipocalin (NGAL) is elevated in type 2 diabetics with carotid artery stenosis and reduced under metformin treatment.Cardiovascular diabetology · 2017Article
- Extracellular molecules in hematopoietic stem cell mobilisation.International journal of hematology · 2017Review
- Hemostasis keeps the stem cell niche in order.Blood · 2016Article
- Role of mesenchymal stem cell-derived fibrinolytic factor in tissue regeneration and cancer progression.Cellular and molecular life sciences : CMLS · 2015Review
- A novel molecule Me6TREN promotes angiogenesis via enhancing endothelial progenitor cell mobilization and recruitment.Scientific reports · 2014Article
- Plasminogen regulates cardiac repair after myocardial infarction through its noncanonical function in stem cell homing to the infarcted heart.Journal of the American College of Cardiology · 2014Article
- The CXCR4/SDF1 axis improves muscle regeneration through MMP-10 activity.Stem cells and development · 2014Article
- Lp(a)/apo(a) modulate MMP-9 activation and neutrophil cytokines in vivo in inflammation to regulate leukocyte recruitment.The American journal of pathology · 2014Article
- The role of novel and known extracellular matrix and adhesion molecules in the homeostatic and regenerative bone marrow microenvironment.Cell adhesion & migration · 2014Review
- Cerebral ischaemia and matrix metalloproteinase-9 modulate the angiogenic function of early and late outgrowth endothelial progenitor cells.Journal of cellular and molecular medicine · 2013Article
- CD164 regulates the tumorigenesis of ovarian surface epithelial cells through the SDF-1α/CXCR4 axis.Molecular cancer · 2013Article
- New functions of the fibrinolytic system in bone marrow cell-derived angiogenesis.International journal of hematology · 2012Review
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
objectiveGranulocyte colony-stimulating factor (G-CSF) is a widespread therapeutic agent for stimulation of hematopoietic progenitor and stem cell (HPSC) mobilization from bone marrow (BM). Plasminogen (Plg) has been shown to be critical for HPSC mobilization. Here, we investigated the role of Plg in G-CSF-induced HPSC mobilization and the underlying mechanism. METHODS AND
resultsBy using gene-targeted mice, our data show that Plg is required for G-CSF-induced HPSC egress to sinusoidal capillaries in BM and subsequent mobilization to peripheral circulation. G-CSF induced Plg-dependent activation of matrix metalloproteinase-9 (MMP-9) in BM, and MMP-9 neutralization or deficiency suppressed HPSC migration and mobilization. Reconstitution of MMP-9 activity by BM transplantation after lentiviral overexpression rescued HPSC mobilization in Plg-deficient mice, indicating that MMP-9 activation is required for Plg-mediated HPSC mobilization. Interestingly, after G-CSF simulation, Plg downregulated stromal cell-derived factor-1 in BM and spatiotemporally regulated the expression of C-X-C chemokine receptor type 4 (CXCR4) on mobilized HPSCs, and reconstitution of MMP-9 activity in Plg-deficient mice reversed CXCR4 expression on HPSCs in plasma and BM, suggesting that CXCR4 serves as a new downstream signal of Plg/MMP-9 in HPSC mobilization.
conclusionsOur data elucidated a novel mechanism that Plg regulates MMP-9-dependent CXCR4 expression to facilitate HPSC mobilization in response to G-CSF.
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Registered trials
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