ArticleJournal of applied physiology (Bethesda, Md. : 1985)2011
Blood pressure changes alter tracheobronchial cough: computational model of the respiratory-cough network and in vivo experiments in anesthetized cats.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 45 citations in OpenAlex.
- Peripheral antitussives affect temporal features of tracheobronchial coughing in cats.Journal of applied physiology (Bethesda, Md. : 1985) · 2025Article
- The role of neuronal excitation and inhibition in the pre-Bötzinger complex on the cough reflex in the cat.Journal of neurophysiology · 2022Article
- Differential effects of acute cerebellectomy on cough in spontaneously breathing cats.PloS one · 2021Article
- Blood pressure drives multispectral tuning of inspiration via a linked-loop neural network.Journal of neurophysiology · 2020Article
- Carotid Bodies and the Integrated Cardiorespiratory Response to Hypoxia.Physiology (Bethesda, Md.) · 2018Review
- Opposing effects of bronchopulmonary C-fiber subtypes on cough in guinea pigs.American journal of physiology. Regulatory, integrative and comparative physiology · 2018Article
- Effects of ion channel noise on neural circuits: an application to the respiratory pattern generator to investigate breathing variability.Journal of neurophysiology · 2017Article
- Cough modulation by upper airway stimuli in cat - potential clinical application?Open journal of molecular and integrative physiology · 2016Article
- Feed-forward and reciprocal inhibition for gain and phase timing control in a computational model of repetitive cough.Journal of applied physiology (Bethesda, Md. : 1985) · 2016Article
- Role of the dorsal medulla in the neurogenesis of airway protection.Pulmonary pharmacology & therapeutics · 2015Review
- Peripheral chemoreceptors tune inspiratory drive via tonic expiratory neuron hubs in the medullary ventral respiratory column network.Journal of neurophysiology · 2015Article
- Physiological and pathophysiological interactions between the respiratory central pattern generator and the sympathetic nervous system.Progress in brain research · 2014Review
- Influence of baclofen on laryngeal and spinal motor drive during cough in the anesthetized cat.The Laryngoscope · 2013Article
- Coordination of cough and swallow: a meta-behavioral response to aspiration.Respiratory physiology & neurobiology · 2013Article
- Suppression of the cough reflex by α 2-adrenergic receptor agonists in the rabbit.Physiological reports · 2013Article
- Resuscitation and auto resuscitation by airway reflexes in animals.Cough (London, England) · 2013Article
- Discharge Identity of Medullary Inspiratory Neurons is Altered during Repetitive Fictive Cough.Frontiers in physiology · 2012Article
- Modulation of the cough reflex by GABA(A) receptors in the caudal ventral respiratory group of the rabbit.Frontiers in physiology · 2012Article
- A joint computational respiratory neural network-biomechanical model for breathing and airway defensive behaviors.Frontiers in physiology · 2012Article
- Computational models for the study of heart-lung interactions in mammals.Wiley interdisciplinary reviews. Systems biology and medicineReview
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
Abstract
We tested the hypothesis, motivated in part by a coordinated computational cough network model, that alterations of mean systemic arterial blood pressure (BP) influence the excitability and motor pattern of cough. Model simulations predicted suppression of coughing by stimulation of arterial baroreceptors. In vivo experiments were conducted on anesthetized spontaneously breathing cats. Cough was elicited by mechanical stimulation of the intrathoracic airways. Electromyograms (EMG) of inspiratory parasternal, expiratory abdominal, laryngeal posterior cricoarytenoid (PCA), and thyroarytenoid muscles along with esophageal pressure (EP) and BP were recorded. Transiently elevated BP significantly reduced cough number, cough-related inspiratory, and expiratory amplitudes of EP, peak parasternal and abdominal EMG, and maximum of PCA EMG during the expulsive phase of cough, and prolonged the cough inspiratory and expiratory phases as well as cough cycle duration compared with control coughs. Latencies from the beginning of stimulation to the onset of cough-related diaphragm and abdominal activities were increased. Increases in BP also elicited bradycardia and isocapnic bradypnea. Reductions in BP increased cough number; elevated inspiratory EP amplitude and parasternal, abdominal, and inspiratory PCA EMG amplitudes; decreased total cough cycle duration; shortened the durations of the cough expiratory phase and cough-related abdominal discharge; and shortened cough latency compared with control coughs. Reduced BP also produced tachycardia, tachypnea, and hypocapnic hyperventilation. These effects of BP on coughing likely originate from interactions between barosensitive and respiratory brainstem neuronal networks, particularly by modulation of respiratory neurons within multiple respiration/cough-related brainstem areas by baroreceptor input.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.