ArticleProceedings of the National Academy of Sciences of the United States of America2011
ATP-sensitive potassium channel (K(ATP))-dependent regulation of cardiotropic viral infections.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 71 citations in OpenAlex.
- Inwardly rectifying potassium channels: Critical insights for insect species and Apis mellifera.Channels (Austin, Tex.) · 2025Review
- Article
- Contribution of glial inwardly rectifying potassium (Kir) channels to potassium buffering in insect neural systems.iScience · 2025Article
- Treatment with mitochondrial targeting antibiotics improves survival outcomes after Flock House virus infection in young and aged Drosophila melanogaster.Research square · 2025Article
- Deformed wing virus coopts the host arginine kinase to enhance its fitness in honey bees (Apis mellifera).BMC biology · 2025Article
- Cloning, functional expression, and pharmacological characterization of inwardly rectifying potassium channels (Kir) from Apis mellifera.Scientific reports · 2024Article
- Acute Adenoviral Infection Elicits an Arrhythmogenic Substrate Prior to Myocarditis.Circulation research · 2024Article
- Do KFrontiers in immunology · 2024Review
- Exploitation of ATP-sensitive potassium ion (KOncogene · 2023Article
- Potassium ion channels as a molecular target to reduce virus infection and mortality of honey bee colonies.Virology journal · 2023Article
- Article
- Pesticide-Virus Interactions in Honey Bees: Challenges and Opportunities for Understanding Drivers of Bee Declines.Viruses · 2020Review
- A Transgenic Flock House Virus Replicon Reveals an RNAi Independent Antiviral Mechanism Acting inG3 (Bethesda, Md.) · 2019Article
- Pharmacological Inhibition of Inward Rectifier Potassium Channels Induces Lethality in LarvalInsects · 2018Article
- Dicer-2 Regulates Resistance and Maintains Homeostasis against Zika Virus Infection inJournal of immunology (Baltimore, Md. : 1950) · 2018Article
- Inward rectifier potassium (Kir) channels in the soybean aphid Aphis glycines: Functional characterization, pharmacology, and toxicology.Journal of insect physiology · 2018Article
- Honey Bee and Bumble Bee Antiviral Defense.Viruses · 2018Review
- Defense Mechanisms against Viral Infection inViruses · 2018Review
- Analysis of the Aedes albopictus C6/36 genome provides insight into cell line utility for viral propagation.GigaScience · 2018Article
- Inwardly Rectifying Potassium (Kir) Channels Represent a Critical Ion Conductance Pathway in the Nervous Systems of Insects.Scientific reports · 2018Article
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
The effects of the cellular environment on innate immunity remain poorly characterized. Here, we show that in Drosophila ATP-sensitive potassium channels (K(ATP)) mediate resistance to a cardiotropic RNA virus, Flock House virus (FHV). FHV viral load in the heart rapidly increases in K(ATP) mutant flies, leading to increased viremia and accelerated death. The effect of K(ATP) channels is dependent on the RNA interference genes Dcr-2, AGO2, and r2d2, indicating that an activity associated with this potassium channel participates in this antiviral pathway in Drosophila. Flies treated with the K(ATP) agonist drug pinacidil are protected against FHV infection, thus demonstrating the importance of this regulation of innate immunity by the cellular environment in the heart. In mice, the Coxsackievirus B3 replicates to higher titers in the hearts of mayday mutant animals, which are deficient in the Kir6.1 subunit of K(ATP) channels, than in controls. Together, our data suggest that K(ATP) channel deregulation can have a critical impact on innate antiviral immunity in the heart.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.