ArticleProceedings of the National Academy of Sciences of the United States of America2011
Spatial control of cell fate using synthetic surfaces to potentiate TGF-beta signaling.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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Who cites it
26 citing papers in PubMed, 53 citations in OpenAlex.
- Directed differentiation of human iPSCs into mesenchymal lineages by optogenetic control of TGF-β signaling.Cell reports · 2023Article
- Bifunctional Peptide that Anneals to Damaged Collagen and Clusters TGF-β Receptors Enhances Wound Healing.ACS chemical biology · 2022Article
- Micro/nanoengineered technologies for human pluripotent stem cells maintenance and differentiation.Nano today · 2021Article
- Spatial Stem Cell Fate Engineering via Facile Morphogen Localization.Advanced healthcare materials · 2021Article
- Spatial localisation meets biomolecular networks.Nature communications · 2021Article
- Bioengineering strategies to control epithelial-to-mesenchymal transition for studies of cardiac development and disease.APL bioengineering · 2021Review
- Modulating Tumor Cell Functions by Tunable Nanopatterned Ligand Presentation.Nanomaterials (Basel, Switzerland) · 2020Review
- Bacteriophage-based biomaterials for tissue regeneration.Advanced drug delivery reviews · 2019Review
- Signals in Stem Cell Differentiation on Fluorapatite-Modified Scaffolds.Journal of dental research · 2018Article
- Material Strategies for Modulating Epithelial to Mesenchymal Transitions.ACS biomaterials science & engineering · 2018Article
- Spatiotemporal Control of TGF-β Signaling with Light.ACS synthetic biology · 2018Article
- Elucidating the molecular mechanisms underlying cellular response to biophysical cues using synthetic biology approaches.Cell adhesion & migration · 2016Review
- Surface functionalization and dynamics of polymeric cell culture substrates.Current opinion in biotechnology · 2016Review
- In vitro selection technologies to enhance biomaterial functionality.Experimental biology and medicine (Maywood, N.J.) · 2016Review
- Cross-Talk Between Human Tenocytes and Bone Marrow Stromal Cells Potentiates Extracellular Matrix Remodeling In Vitro.Journal of cellular biochemistry · 2016Article
- Material Cues as Potent Regulators of Epigenetics and Stem Cell Function.Cell stem cell · 2016Review
- The non-detergent sulfobetaine-201 acts as a pharmacological chaperone to promote folding and crystallization of the type II TGF-β receptor extracellular domain.Protein expression and purification · 2015Article
- Signals from the surface modulate differentiation of human pluripotent stem cells through glycosaminoglycans and integrins.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Human pluripotent stem cell culture: considerations for maintenance, expansion, and therapeutics.Cell stem cell · 2014Review
- Sensitization of transforming growth factor-β signaling by multiple peptides patterned on DNA nanostructures.Biomacromolecules · 2013Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
In organisms, cell-fate decisions result from external cues presented by the extracellular microenvironment or the niche. In principle, synthetic niches can be engineered to give rise to patterned cell signaling, an advance that would transform the fields of tissue engineering and regenerative medicine. Biomaterials that display adhesive motifs are critical steps in this direction, but promoting localized signaling remains a major obstacle. We sought to exert precise spatial control over activation of TGF-β signaling. TGF-β signaling, which plays fundamental roles in development, tissue homeostasis, and cancer, is initiated by receptor oligomerization. We therefore hypothesized that preorganizing the transmembrane receptors would potentiate local TGF-β signaling. To generate surfaces that would nucleate the signaling complex, we employed defined self-assembled monolayers that present peptide ligands to TGF-β receptors. These displays of nondiffusible ligands do not compete with the growth factor but rather sensitize bound cells to subpicomolar concentrations of endogenous TGF-β. Cells adhering to the surfaces undergo TGF-β-mediated growth arrest and the epithelial to mesenchymal transition. Gene expression profiles reveal that the surfaces selectively regulate TGF-β responsive genes. This strategy provides access to tailored surfaces that can deliver signals with spatial control.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.