ArticlePlant physiology2011
The SINA E3 ligase OsDIS1 negatively regulates drought response in rice.
Article in Plant physiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 89 papers, 1 of them a synthesis that pooled it.
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Who cites it
89 citing papers in PubMed, 1 synthesis or guideline pooled it, 203 citations in OpenAlex.
- In silico analysis of the Seven IN Absentia (SINA) genes in bread wheat sheds light on their structure in plants.PloS one · 2023Pooled it
- Identification of the RING-HCa E3 Ligase Gene Family and Functional Characterization ofCurrent issues in molecular biology · 2026Article
- Applications of Gene-Editing Technologies in Enhancing Crop Stress Resistance with Emphasis on Rice.Plants (Basel, Switzerland) · 2026Review
- A rice ceRNA module suppresses Rhizoctonia solani-induced cross-kingdom RNAi to reduce fungal pathogenicity.Nature communications · 2026Article
- Article
- ZmDRZ1 negatively regulates drought tolerance via modulating ABA signaling pathway in maize.Plant cell reports · 2026Article
- Heterologous expression of soybean E3 ubiquitin ligase Glycine max Ring Zinc Finger 1-Like 1 (GmRZFL1) negatively responds to osmotic stress by participating in the abscisic acid signaling pathway in Arabidopsis.BMC plant biology · 2025Article
- Balancing rice blast resistance and growth through suppression of the E3 ubiquitin ligase OsRING80.Plant physiology · 2025Article
- Enhancing drought resilience in crops: mechanistic approaches in the face of climate challenge.Plant molecular biology · 2025Review
- An mNature communications · 2025Article
- Drought-Induced Zinc Finger Transcription Factor OsDi19-3 Positively Regulates Drought Stress Acclimatization in Rice (Plants (Basel, Switzerland) · 2025Article
- Ubiquitin Ligase GenePlants (Basel, Switzerland) · 2025Article
- Grafting enhances drought stress tolerance by regulating the proteome and targeted gene regulatory networks in tomato.Frontiers in plant science · 2025Article
- Exploring physiological and molecular dynamics of drought stress responses in plants: challenges and future directions.Frontiers in plant science · 2025Review
- Transcriptome and Metabolome Analyses Reveal the Regulatory Mechanism ofPlants (Basel, Switzerland) · 2024Article
- Deciphering the mechanism of E3 ubiquitin ligases in plant responses to abiotic and biotic stresses and perspectives on PROTACs for crop resistance.Plant biotechnology journal · 2024Review
- Genome-wide identification of SINA gene family in Medicago truncatula and functional analysis of MtSINAL7.Molecular biology reports · 2024Article
- Genomic-wide analysis reveals seven in absentia genes regulating grain development in wheat (Triticum aestivum L.).The plant genome · 2024Article
- MdSINA2-MdNAC104 Module Regulates Apple Alkaline Resistance by Affecting γ-Aminobutyric Acid Synthesis and Transport.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Article
29 more citing papers are in PubMed but not listed here.
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Authors and funding
14 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ubiquitin-regulated protein degradation is a critical regulatory mechanism that controls a wide range of biological processes in plants. Here, we report that OsDIS1 (for Oryza sativa drought-induced SINA protein 1), a C3HC4 RING finger E3 ligase, is involved in drought-stress signal transduction in rice (O. sativa). The expression of OsDIS1 was up-regulated by drought treatment. In vitro ubiquitination assays showed that OsDIS1 possessed E3 ubiquitin ligase activity and that the conserved region of the RING finger was required for the activity. Transient expression assays in Nicotiana benthamiana leaves and rice protoplasts indicated that OsDIS1 was localized predominantly in the nucleus. Overexpression of OsDIS1 reduced drought tolerance in transgenic rice plants, while RNA interference silencing of OsDIS1 enhanced drought tolerance. Microarray analysis revealed that a large number of drought-responsive genes were induced or suppressed in the OsDIS1 overexpression plants under normal and drought conditions. Yeast two-hybrid screening showed that OsDIS1 interacted with OsNek6 (for O. sativa NIMA-related kinase 6), a tubulin complex-related serine/threonine protein kinase. Coexpression assays in N. benthamiana leaves indicated that OsNek6 was degraded by OsDIS1 via the 26S proteasome-dependent pathway and that this degradation was abolished by the OsDIS1(H71Y) mutation, which is essential for its E3 ligase activity. Together, these results demonstrate that OsDIS1 plays a negative role in drought stress tolerance through transcriptional regulation of diverse stress-related genes and possibly through posttranslational regulation of OsNek6 in rice.
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