ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2011
Elevated interferon gamma signaling contributes to impaired regeneration in the aged liver.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 35 citations in OpenAlex.
- Review
- Regenerative loss in the animal kingdom as viewed from the mouse digit tip and heart.Developmental biology · 2024Review
- Age-related differences in response to plasma exchange in male rat liver tissues: insights from histopathological and machine-learning assisted spectrochemical analyses.Biogerontology · 2023Article
- The Roles of Myeloid Cells in Aging-related Liver Diseases.International journal of biological sciences · 2023Review
- Understanding the Unique Microenvironment in the Aging Liver.Frontiers in medicine · 2022Review
- Aging Leads to Increased Monocytes and Macrophages With Altered CSF-1 Receptor Expression and Earlier Tumor-Associated Macrophage Expansion in Murine Mesothelioma.Frontiers in aging · 2022Article
- Tissue-Dependent Adaptations and Functions of Innate Lymphoid Cells.Frontiers in immunology · 2022Review
- Adipose-tissue derived porcine mesenchymal stem cells efficiently ameliorate CClCytotechnology · 2020Article
- Immune - Goblet cell interaction in the conjunctiva.The ocular surface · 2020Review
- Article
- Effects of apoptosis on liver aging.World journal of clinical cases · 2019Review
- Immunogenetics of new onset diabetes after transplantation in Kuwait.Diabetes, metabolic syndrome and obesity : targets and therapy · 2019Article
- Liver regeneration in aged mice: new insights.Aging · 2018Review
- Global gene expression profile of normal and regenerating liver in young and old mice.Age (Dordrecht, Netherlands) · 2015Article
- Nonalcoholic fatty liver disease and aging: epidemiology to management.World journal of gastroenterology · 2014Review
- Molecular alterations in proteasomes of rat liver during aging result in altered proteolytic activities.Age (Dordrecht, Netherlands) · 2014Article
- Deletion of IFNγ enhances hepatocarcinogenesis in FXR knockout mice.Journal of hepatology · 2012Article
- Integrative genomics: liver regeneration and hepatocellular carcinoma.Journal of cellular biochemistry · 2012Article
- Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Our previous study on immune-related changes in the aged liver described immune cell infiltration and elevation of inflammation with age. Levels of interferon (IFN)-γ, a known cell cycle inhibitor, were elevated in the aging liver. Here, we determine the role played by IFN-γ in the delayed regenerative response observed in the aged livers. We observed elevated IFN signaling in both aged hepatocytes and regenerating livers post-partial hepatectomy. In vivo deletion of the major IFN-γ producers-the macrophages and the natural killer cells, leads to a reduction in the IFN-γ levels accompanied with the restoration of the DNA synthesis kinetics in the aged livers. Eighteen-month-old IFN-γ-/- mice livers, upon resection, exhibited an earlier entry into the cell cycle compared with age-matched controls. Thus, our study strongly suggests that an age-related elevation in inflammatory conditions in the liver often dubbed as "inflammaging" has a detrimental effect on the regenerative response.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.