ArticleEuropean journal of medical research2011
Respiratory symptoms in preterm infants: burden of disease in the first year of life.
Article in European journal of medical research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05063149 (Protecting Late-moderate Preterm Infants From Respiratory Tract Infections and Wheeze in Their First Years of Life by Using Bacterial Lysates.), which is not on this map. Cited by 29 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Protecting Late-moderate Preterm Infants From Respiratory Tract Infections and Wheeze in Their First Years of Life by Using Bacterial Lysates.
Who cites it
29 citing papers in PubMed, 2 syntheses or guidelines pooled it, 76 citations in OpenAlex.
- Prevalence of preterm birth in Scandinavian countries: a systematic review and meta-analysis.The Journal of international medical research · 2023Pooled it
- Outpatient Respiratory Management of Infants, Children, and Adolescents with Post-Prematurity Respiratory Disease: An Official American Thoracic Society Clinical Practice Guideline.American journal of respiratory and critical care medicine · 2021Guideline
- Association between intermittent hypoxemia and COVID-19 related isolation and pulmonary outcomes through 2 years of age in infants born preterm.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- A primary cell model of the very preterm epithelium reveals barrier defects at 1 year of age.ERJ open research · 2025Article
- Long-term respiratory outcomes in school-aged children born before 32 weeks of gestation.European journal of pediatrics · 2025Observational
- Article
- Transcriptomic analysis of primary nasal epithelial cells reveals altered interferon signalling in preterm birth survivors at one year of age.Frontiers in cell and developmental biology · 2024Article
- Article
- Oscillometry and spirometry are not interchangeable when assessing the bronchodilator response in children and young adults born preterm.Pediatric pulmonology · 2023Article
- Are Babies Born Preterm High-Risk Asthma Candidates?Journal of clinical medicine · 2023Review
- Prematurity-associated wheeze: current knowledge and opportunities for further investigation.Pediatric research · 2023Review
- Prematurity and BPD: what general pediatricians should know.European journal of pediatrics · 2023Review
- Respiratory morbidity in preschool and school-age children born very preterm and its association with parents' health-related quality of life and family functioning.European journal of pediatrics · 2023Article
- Discharge Practices for Infants with Bronchopulmonary Dysplasia: A Survey of National Experts.The Journal of pediatrics · 2023Article
- Growth and differentiation factor 15 (GDF15) levels predict adverse respiratory outcomes in premature neonates.Pediatric pulmonology · 2023Article
- Article
- Lung growth and pulmonary function after prematurity and bronchopulmonary dysplasia.Pediatric pulmonology · 2021Review
- Early Life Factors Associated with Preschool Wheezing in Preterm Infants.Children (Basel, Switzerland) · 2021Article
- Cigarette Smoke Exposure, Pediatric Lung Disease, and COVID-19.Frontiers in physiology · 2021Review
- Non-invasive Ventilation for Children With Chronic Lung Disease.Frontiers in pediatrics · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveWhile respiratory symptoms in the first year of life are relatively well described for term infants, data for preterm infants are scarce. We aimed to describe the burden of respiratory disease in a group of preterm infants with and without bronchopulmonary dysplasia (BPD) and to assess the association of respiratory symptoms with perinatal, genetic and environmental risk factors.
methodsSingle centre birth cohort study: prospective recording of perinatal risk factors and retrospective assessment of respiratory symptoms during the first year of life by standardised questionnaires.
main outcome measuresCough and wheeze (common symptoms), re-hospitalisation and need for inhalation therapy (severe outcomes). PATIENTS: 126 preterms (median gestational age 28.7 weeks; 78 with, 48 without BPD) hospitalised at the University Children's Hospital of Bern, Switzerland 1999-2006.
resultsCough occurred in 80%, wheeze in 44%, re-hospitalisation in 25% and long term inhalation therapy in wheezers in 13% of the preterm infants. Using logistic regression, the main risk factor for common symptoms was frequent contact with other children. Severe outcomes were associated with maximal peak inspiratory pressure, arterial cord blood pH, APGAR- and CRIB-Score.
conclusionsCough in preterm infants is as common as in term infants, whereas wheeze, inhalation therapy and re-hospitalisations occur more often. Severe outcomes are associated with perinatal risk factors. Preterm infants who did not qualify for BPD according to latest guidelines also showed a significant burden of respiratory disease in the first year of life.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.