ArticleEnvironmental health perspectives2011
Thyroid dysfunction as a mediator of organochlorine neurotoxicity in preschool children.
Article in Environmental health perspectives, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.
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Who cites it
10 citing papers in PubMed, 2 syntheses or guidelines pooled it, 24 citations in OpenAlex.
- A Meta-Analysis of Stressors from the Total Environment Associated with Children's General Cognitive Ability.International journal of environmental research and public health · 2020Pooled it
- Contributions of a Child's Built, Natural, and Social Environments to Their General Cognitive Ability: A Systematic Scoping Review.PloS one · 2016Pooled it
- Cross-Sectional Examination of Thyroid Hormones and Environmental Exposure to Multiclass Pesticides in Women of Reproductive Age in China.Environmental health perspectives · 2024Article
- Marine pollutant exposures and human milk extracellular vesicle-microRNAs in a mother-infant cohort from the Faroe Islands.Environment international · 2022Article
- Associations of Exposure to Perfluoroalkyl Substances With Thyroid Hormone Concentrations and Birth Size.The Journal of clinical endocrinology and metabolism · 2020Article
- Residue Levels of Organochlorine Pesticides in Breast Milk and Its Associations with Cord Blood Thyroid Hormones and the Offspring's Neurodevelopment.International journal of environmental research and public health · 2019Article
- Prenatal and Postnatal PCB-153 andEnvironmental health perspectives · 2017Article
- Prenatal p,p'-DDE exposure and establishment of lateralization and spatial orientation in Mexican preschooler.Neurotoxicology · 2015Article
- Prenatal p,p´-DDE exposure and neurodevelopment among children 3.5-5 years of age.Environmental health perspectives · 2013Article
- Neurobehavioral deficits at age 7 years associated with prenatal exposure to toxicants from maternal seafood diet.Neurotoxicology and teratology · 2012Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 3 countries.
Funding
Abstract
backgroundExposure to organochlorine compounds (OCs) can alter thyroid function in humans, and hypothyroidism during early life can adversely affect a child's neurodevelopment.
objectivesIn this study we aimed to assess the relationship between developmental organochlorine exposures and thyroid function and the relationship between thyroid function and subsequent neurodevelopment.
methodsA population-based birth cohort of 182 children was followed annually up to 5.5 years of age. The assessments included OC concentrations in maternal pregnancy serum and milk, clinical thyroid parameters in maternal and cord serum, and subsequent neuropsychological outcomes of the child, along with sociodemographic cofactors. Resin triiodothyronine uptake ratio (T3RU) was also assessed as an estimate of the amount of thyroxine-binding globulin (TBG) sites unsaturated by thyroxine. The T3RU is high in hyperthyroidism and low in hypothyroidism.
resultsThe findings showed consistent inverse and monotonic associations between organochlorine exposure and T3RU after covariate adjustments. We observed no associations with other thyroid parameters. T3RU was positively associated with improved performance on most of the neuropsychological tests. For other thyroid parameters, the findings were less consistent.
conclusionsThe results suggest that OC exposures may decrease the T3RU during early life, which is a proxy measure of the binding capacity of TBG. In addition, minor decreases of the thyroid function may be inversely associated with a child's neurodevelopment.
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