ArticleBiological psychiatry2011
Altered temporal difference learning in bulimia nervosa.
Article in Biological psychiatry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers, 3 of them syntheses that pooled it.
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Who cites it
81 citing papers in PubMed, 3 syntheses or guidelines pooled it, 125 citations in OpenAlex.
- A Systematic Review of Taste Differences Among People With Eating Disorders.Biological research for nursing · 2020Pooled it
- An interoceptive model of bulimia nervosa: A neurobiological systematic review.Journal of psychiatric research · 2017Pooled it
- Reinforcement learning models and their neural correlates: An activation likelihood estimation meta-analysis.Cognitive, affective & behavioral neuroscience · 2015Pooled it
- Ketone Supplementation Attenuates Prediction Error Taste Response in Eating Disorders: A Proof-of-Concept Study.The International journal of eating disorders · 2026Trial
- The effects of energy balance, obesity-proneness and sex on the neuronal response to sweet taste.Behavioural brain research · 2015Trial
- A neurodevelopmental model of eating disorder risk in midlife to older adulthood.Neuroscience and biobehavioral reviews · 2026Review
- Prefrontal and ventral striatal neural correlates of reversal learning in anorexia nervosa and bulimia nervosa.Cognitive, affective & behavioral neuroscience · 2026Article
- Altered amygdala and striatal responsivity and prediction error encoding of temporal reward dynamics in post-trauma psychopathology.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Transdiagnostic Neurobiological and Nutritional Factors in Eating Disorders: Implications for Integrative Treatment Models.Nutrients · 2026Review
- Psilocybin Treatment as an Adjunct to Cognitive Behavioral Therapy for Eating Disorders: Therapeutic Rationale & Considerations for Protocol Development.Behavioral sciences (Basel, Switzerland) · 2026Review
- Lesions involving the insula are associated with reduced appetite and weight loss.Brain communications · 2026Article
- Addressing Altered Anticipation as a Transdiagnostic Target Through Computational Psychiatry.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2025Review
- Perceptual Dysfunction in Eating Disorders.Current topics in behavioral neurosciences · 2025Review
- Exploring the thalamus: a crucial hub for brain function and communication in patients with bulimia nervosa.Journal of eating disorders · 2023Article
- Back to the future: Progressing memory research in eating disorders.The International journal of eating disorders · 2023Article
- Central Regulation of Eating Behaviors in Humans: Evidence from Functional Neuroimaging Studies.Nutrients · 2023Review
- State-specific alterations in the neural computations underlying inhibitory control in women remitted from bulimia nervosa.Molecular psychiatry · 2023Article
- Altered prefrontal activation during the inhibition of eating responses in women with bulimia nervosa.Psychological medicine · 2023Article
- Exploration of the relationships between clinical traits and functional connectivity based on surface morphology abnormalities in bulimia nervosa.Brain and behavior · 2023Article
- Impaired belief updating and devaluation in adult women with bulimia nervosa.Translational psychiatry · 2023Article
21 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundThe neurobiology of bulimia nervosa (BN) is poorly understood. Recent animal literature suggests that binge eating is associated with altered brain dopamine (DA) reward function. In this study, we wanted to investigate DA-related brain reward learning in BN.
methodsIll BN (n = 20, age: mean = 25.2, SD = 5.3 years) and healthy control women (CW) (n = 23, age: mean = 27.2, SD = 6.4 years) underwent functional magnetic resonance brain imaging together with application of a DA-related reward learning paradigm, the temporal difference (TD) model. That task involves association learning between conditioned visual and unconditioned taste stimuli, as well as unexpected violation of those learned associations. Study participants also completed the Sensitivity to Reward and Punishment Questionnaire.
resultsBulimia nervosa individuals showed reduced brain response compared with CW for unexpected receipt and omission of taste stimuli, as well as reduced brain regression response to the TD computer model generated reward values, in insula, ventral putamen, amygdala, and orbitofrontal cortex. Those results were qualitatively similar in BN individuals who were nondepressed and unmedicated. Binge/purge frequency in BN inversely predicted reduced TD model response. Bulimia nervosa individuals showed significantly higher Sensitivity to Reward and Punishment compared with CW.
conclusionsThis is the first study that relates reduced brain DA responses in BN to the altered learning of associations between arbitrary visual stimuli and taste rewards. This attenuated response is related to frequency of binge/purge episodes in BN. The brain DA neurotransmitter system could be an important treatment target for BN.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.