ArticleJournal of the American College of Cardiology2011
Impaired fasting glucose and the risk of incident diabetes mellitus and cardiovascular events in an adult population: MESA (Multi-Ethnic Study of Atherosclerosis).
Article in Journal of the American College of Cardiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers, 5 of them syntheses that pooled it.
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Who cites it
69 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- 2026 AHA/ACC/ADA/ASN Guideline for the Prevention, Detection, Evaluation, and Management of Cardiovascular-Kidney-Metabolic Syndrome: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines.Journal of the American College of Cardiology · 2026Guideline
- Development of type 2 diabetes mellitus in people with intermediate hyperglycaemia.The Cochrane database of systematic reviews · 2018Pooled it
- Association between prediabetes and risk of cardiovascular disease and all cause mortality: systematic review and meta-analysis.BMJ (Clinical research ed.) · 2016Pooled it
- Risk of Coronary Heart Disease in Different Criterion of Impaired Fasting Glucose: A Meta-Analysis.Medicine · 2015Pooled it
- Effect of pre-diabetes on future risk of stroke: meta-analysis.BMJ (Clinical research ed.) · 2012Pooled it
- Trial
- Trial
- Predictors for glucose change in hypertensive participants following short-term treatment with atenolol or hydrochlorothiazide.Pharmacotherapy · 2014Trial
- Impaired fasting glucose and body mass index as determinants of mortality in ALLHAT: is the obesity paradox real?Journal of clinical hypertension (Greenwich, Conn.) · 2014Trial
- Associations of drinking water and urinary uranium with incident diabetes among U.S. adults: The Multi-Ethnic Study of Atherosclerosis and the Strong Heart Family Study.Environmental research · 2026Article
- Determination, Validation, and Development of Prediction Scores Related to Hypoglycemia Risk Factors Among Ambulatory Type 2 Diabetes Mellitus Patients in Bali, Indonesia.Current diabetes reviews · 2026Article
- Metformin Prescription Orders among Patients with Prediabetes in a National Network of Federally Qualified Health Centers.Journal of general internal medicine · 2026Article
- Epidemiological features and prevalence patterns of prediabetes outcomes in an east coast Malaysian cohort: A retrospective cohort study.Malaysian family physician : the official journal of the Academy of Family Physicians of Malaysia · 2026Article
- Life's essential 8 and risk of progression to diabetes among young adults with prediabetes.Scientific reports · 2025Article
- Fasting glucose improvement following a short-term, culturally adapted lifestyle intervention in Latino adults at risk for type 2 diabetes mellitus: a quasi-experimental study.BMC nutrition · 2025Article
- Metabolomics Profiling of Epicardial Adipose Tissue: MESA and the Rotterdam Study.Journal of the American Heart Association · 2025Article
- Association of Water Arsenic With Incident Diabetes in U.S. Adults: The Multi-Ethnic Study of Atherosclerosis and the Strong Heart Study.Diabetes care · 2024Article
- Effect of fasting glucose levels on carotid intima-media thickness in premenopausal versus postmenopausal women.Archives of endocrinology and metabolism · 2024Article
- The associations of risk of cardiovascular disease with development stages of diabetes in Chinese population: findings from a retrospective cohort study in QuZhou city.BMC endocrine disorders · 2024Article
- IgE to common food allergens is associated with cardiovascular mortality in the National Health and Examination Survey and the Multi-Ethnic Study of Atherosclerosis.The Journal of allergy and clinical immunology · 2024Article
9 more citing papers are in PubMed but not listed here.
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Funding
Abstract
objectivesThe purpose of the study was to assess the cardiovascular risk of impaired fasting glucose (IFG).
backgroundThe associations between IFG, incident type 2 diabetes mellitus (T2DM), and cardiovascular (CV) events remains unclear.
methodsThe MESA (Multi-Ethnic Study of Atherosclerosis) study included participants who were 45 to 84 years or age and free of clinical CV disease at baseline (2000 to 2002). Type 2 DM was defined as fasting glucose >125 mg/dl or receiving antidiabetes medication at baseline and follow-up examinations; IFG was defined as no T2DM and fasting glucose 100 to 125 mg/dl. Cox proportional hazards analysis was used to assess the association between IFG and incident DM and also between IFG and incident CV events.
resultsOf 6,753 participants included in these analyses, 840 (12.7%) had T2DM and 940 (13.8%) had IFG at the baseline examination. During 7.5 years of follow-up, there were 418 adjudicated CV events. Type 2 DM was associated with an increased CV incidence in the univariate model (hazard ratio [HR]: 2.83, 95% confidence interval [CI]: 2.25 to 3.56, p < 0.0001) and multivariate model adjusted for demographics and traditional risk factors (HR: 1.87, 95% CI: 1.47 to 2.37, p < 0.0001) compared with subjects not having T2DM (IFG plus normal fasting glucose). Impaired fasting glucose was associated with increased incidence of T2DM (HR: 13.2, 95% CI: 10.8 to 16.2, p < 0.001) that remained after adjusting for demographics, highest educational level, physical activity, and body mass index (HR: 10.5, 95% CI: 8.4 to 13.1, p < 0.001) compared with normal fasting glucose. Impaired fasting glucose was associated with incident CV events in the univariate model (HR: 1.64, 95% CI: 1.26 to 2.14, p < 0.001) but not in the full multivariate model (HR: 1.16, 95% CI: 0.88 to 1.52, p = 0.3) compared with normal fasting glucose.
conclusionsHaving IFG was not independently associated with an increased short-term risk for incident CV events. These data reiterate the importance of intervention for persons with IFG to reduce their incidence of T2DM.
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