SynthesisBMJ clinical evidence2010
Constipation in people prescribed opioids.
Synthesis in BMJ clinical evidence, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed.
- Long-term safety and efficacy of oxycodone/naloxone prolonged-release tablets in patients with moderate-to-severe chronic cancer pain.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2015Trial
- A randomized, double-blind, active-controlled, double-dummy, parallel-group study to determine the safety and efficacy of oxycodone/naloxone prolonged-release tablets in patients with moderate/severe, chronic cancer pain.Palliative medicine · 2012Trial
- Trends in polypharmacy and potentially inappropriate medication (PIM) in older and middle-aged people treated for diabetes.British journal of clinical pharmacology · 2021Article
- Updates in palliative care - recent advancements in the pharmacological management of symptoms.Clinical medicine (London, England) · 2018Review
- Managing Constipation in Adults With Cancer.Journal of the advanced practitioner in oncology · 2017Review
- Constipation in specialized palliative care: factors related to constipation when applying different definitions.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2016Article
- Efficacy and tolerability balance of oxycodone/naloxone and tapentadol in chronic low back pain with a neuropathic component: a blinded end point analysis of randomly selected routine data from 12-week prospective open-label observations.Journal of pain research · 2016Article
- Evolving paradigms in the treatment of opioid-induced bowel dysfunction.Therapeutic advances in gastroenterology · 2015Review
- Side effects of analgesia may significantly reduce quality of life in symptomatic multiple myeloma: a cross-sectional prevalence study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2015Article
- Dejection and self-assessment of quality of life in patients with lung cancer subjected to palliative care.Contemporary oncology (Poznan, Poland) · 2015Article
- Developments in managing severe chronic pain: role of oxycodone-naloxone extended release.Drug design, development and therapy · 2015Review
- Oxycodone/Naloxone: role in chronic pain management, opioid-induced constipation, and abuse deterrence.Pain and therapy · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionConstipation is reported in 52% of people with advanced malignancy. This figure rises to 87% in people who are terminally ill and taking opioids. Constipation may be the most common adverse effect of opioids. There is no reason to believe that people with chronic non-malignant disease who take opioids will be any less troubled by this adverse effect. METHODS AND OUTCOMES: We conducted a systematic review and aimed to answer the following clinical questions: What are the effects of: oral laxatives, rectally applied medications, and opioid antagonists for constipation in people prescribed opioids? We searched: Medline, Embase, The Cochrane Library, and other important databases up to August 2009 (Clinical Evidence reviews are updated periodically, please check our website for the most up-to-date version of this review). We included harms alerts from relevant organisations such as the US Food and Drug Administration (FDA) and the UK Medicines and Healthcare products Regulatory Agency (MHRA).
resultsWe found 23 systematic reviews, RCTs, or observational studies that met our inclusion criteria. We performed a GRADE evaluation of the quality of evidence for interventions.
conclusionsIn this systematic review we present information relating to the effectiveness and safety of the following interventions: arachis oil enemas, bisacodyl, co-danthrusate/co-danthramer, docusate, glycerol suppositories, ispaghula husk, lactulose, liquid paraffin, macrogols plus electrolyte solutions, magnesium salts, methylcellulose, opioid antagonists, phosphate enemas, senna, sodium citrate micro-enema, and sodium picosulfate.
Indexed as
Identifiers
21718572PMC2907601What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.