ArticleBMC genomics2011
Genome-wide expression quantitative trait loci (eQTL) analysis in maize.
Article in BMC genomics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 74 citations in OpenAlex.
- Alterations in Growth Habit to Channel End-of-Season Perennial Reserves towards Increased Yield and Reduced Regrowth after Defoliation in Upland Cotton (International journal of molecular sciences · 2023Article
- Mapping responsive genomic elements to heat stress in a maize diversity panel.Genome biology · 2022Article
- Article
- Genome-wide analysis of deletions in maize population reveals abundant genetic diversity and functional impact.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2022Article
- Article
- Interpreting Functional Impact of Genetic Variations by Network QTL for Genotype-Phenotype Association Study.Frontiers in cell and developmental biology · 2021Article
- Identification of miRNA-eQTLs in maize mature leaf by GWAS.BMC genomics · 2020Article
- Xylem systems genetics analysis reveals a key regulator of lignin biosynthesis inGenome research · 2020Article
- Dynamic patterns of circular and linear RNAs in maize hybrid and parental lines.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2020Article
- Analysis of the genetic architecture of maize kernel size traits by combined linkage and association mapping.Plant biotechnology journal · 2020Article
- The Role of Transcriptional Regulation in Hybrid Vigor.Frontiers in plant science · 2020Review
- Characterization of Proteome Variation During Modern Maize Breeding.Molecular & cellular proteomics : MCP · 2019Article
- Complex Relationships between Chromatin Accessibility, Sequence Divergence, and Gene Expression in Arabidopsis thaliana.Molecular biology and evolution · 2018Article
- Integrated QTL and eQTL Mapping Provides Insights and Candidate Genes for Fatty Acid Composition, Flowering Time, and Growth Traits in a FFrontiers in plant science · 2018Article
- Gene co-expression network connectivity is an important determinant of selective constraint.PLoS genetics · 2017Article
- Quantitative Trait Locus Analysis for Deep-Sowing Germination Ability in the Maize IBM Syn10 DH Population.Frontiers in plant science · 2017Article
- eQTLs Regulating Transcript Variations Associated with Rapid Internode Elongation in Deepwater Rice.Frontiers in plant science · 2017Article
- Evaluation of the utility of gene expression and metabolic information for genomic prediction in maize.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2016Article
- Adrenal cortex expression quantitative trait loci in a German Holstein × Charolais cross.BMC genetics · 2016Article
- Expression profiling of genes involved in drought stress and leaf senescence in juvenile barley.BMC plant biology · 2016Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundExpression QTL analyses have shed light on transcriptional regulation in numerous species of plants, animals, and yeasts. These microarray-based analyses identify regulators of gene expression as either cis-acting factors that regulate proximal genes, or trans-acting factors that function through a variety of mechanisms to affect transcript abundance of unlinked genes.
resultsA hydroponics-based genetical genomics study in roots of a Zea mays IBM2 Syn10 double haploid population identified tens of thousands of cis-acting and trans-acting eQTL. Cases of false-positive eQTL, which results from the lack of complete genomic sequences from both parental genomes, were described. A candidate gene for a trans-acting regulatory factor was identified through positional cloning. The unexpected regulatory function of a class I glutamine amidotransferase controls the expression of an ABA 8'-hydroxylase pseudogene.
conclusionsIdentification of a candidate gene underlying a trans-eQTL demonstrated the feasibility of eQTL cloning in maize and could help to understand the mechanism of gene expression regulation. Lack of complete genome sequences from both parents could cause the identification of false-positive cis- and trans-acting eQTL.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.