ArticleJournal of the American Geriatrics Society2011
Forced expiratory volume in 1 second and cognitive aging in men.
Article in Journal of the American Geriatrics Society, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 4 syntheses or guidelines pooled it, 33 citations in OpenAlex.
- Systematic Review of Pulmonary Function and Cognition in Aging.The journals of gerontology. Series B, Psychological sciences and social sciences · 2020Pooled it
- A Multi-study Coordinated Meta-analysis of Pulmonary Function and Cognition in Aging.The journals of gerontology. Series A, Biological sciences and medical sciences · 2019Pooled it
- The relationship between cognitive function and arterial partial pressure O2 in patients with COPD: A meta-analysis.Medicine · 2018Pooled it
- The dynamic relationship between physical function and cognition in longitudinal aging cohorts.Epidemiologic reviews · 2013Pooled it
- Exploring the relative contributions of multiple modifiable physical health variables to executive function and episodic memory performance in older adults.Neuropsychology · 2026Article
- Association of Lung Function With Cognitive Decline and Incident Dementia in the Atherosclerosis Risk in Communities Study.American journal of epidemiology · 2023Article
- Association between pulmonary ventilatory function and mild cognitive impairment: A population-based study in rural China.Frontiers in public health · 2022Article
- Association of Pulmonary Function With Cognitive Decline in Older Adults: A Nationwide Longitudinal Study in China.The journals of gerontology. Series A, Biological sciences and medical sciences · 2021Article
- Poor Cognitive Function Is Associated with Obstructive Lung Diseases in Taiwanese Adults.International journal of environmental research and public health · 2021Article
- Reduced Lung Function and Cognitive Decline in Aging: A Longitudinal Cohort Study.Annals of the American Thoracic Society · 2021Article
- Associations Between Declining Physical and Cognitive Functions in the Lothian Birth Cohort 1936.The journals of gerontology. Series A, Biological sciences and medical sciences · 2020Article
- Cognitive status among patients with chronic obstructive pulmonary disease.International journal of chronic obstructive pulmonary disease · 2016Article
- Associations of Pulmonary Function with Dementia and Depression in an Older Korean Population.Psychiatry investigation · 2015Article
- Cognition and health in African American men.Journal of aging and health · 2015Article
- Short-term prognostic value of forced expiratory volume in 1 second divided by height cubed in a prospective cohort of people 80 years and older.BMC geriatrics · 2015Article
- Lung disease as a determinant of cognitive decline and dementia.Alzheimer's research & therapy · 2015Article
- Variants of asthma and chronic obstructive pulmonary disease genes and lung function decline in aging.The journals of gerontology. Series A, Biological sciences and medical sciences · 2014Article
- Association between non-cystic fibrosis bronchiectasis and the risk of incident dementia: A nationwide cohort study.Chronic respiratory diseaseArticle
- Breathe Easy, Speak Easy: Pulmonary Function and Language Performance in Aging.Experimental aging researchArticle
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
objectivesTo evaluate forced expiratory volume in 1 second (FEV(1) , a measure of overall lung function), long-term average FEV(1) , and rate of decline in FEV(1) in relation to cognition and cognitive decline in older men.
designProspective observational study.
settingCommunity-based population.
participantsEight hundred sixty-four older men from the Normative Aging Study. MEASUREMENTS: Starting in 1984, participants underwent triennial clinical evaluations. Lung function assessments provided estimates of FEV(1) . Cognitive assessments entailing tests of several cognitive abilities began in 1993. FEV(1) measured approximately 12 years before baseline cognitive testing, average FEV(1) over the 12-year period, and rate of change in FEV(1) were all evaluated in relation to baseline and change in performance on the cognitive tests.
resultsIn multivariable-adjusted analyses, associations between FEV(1) and baseline cognitive scores were mixed, although average FEV(1) predicted significantly better performance on tests of visuospatial ability (P=.04) and general cognition (P=.03). Higher FEV(1) was more consistently associated with slower cognitive decline, but only the association between historical FEV(1) and attention was significant (difference per standard deviation in FEV(1) =0.056, P=.05). Rate of FEV(1) decline was not consistently associated with cognitive function or decline. Findings were generally similar or stronger in men who had never smoked. To account for potential bias due to selective attrition, inverse probability of censoring weights were applied to the cognitive decline analyses, yielding slightly larger estimates; the inadequate prognostic power of the censoring models limited this approach.
conclusionOverall, the data provide limited evidence of an inverse association between FEV(1) and cognitive aging.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.