ArticleNanomedicine (London, England)2011
Gold nanorod--siRNA induces efficient in vivo gene silencing in the rat hippocampus.
Article in Nanomedicine (London, England), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed.
- Multifunctional Gold Nanoparticles for Improved Diagnostic and Therapeutic Applications: A Review.Nanoscale research letters · 2021Review
- Multifunctional Gold Nanorod for Therapeutic Applications and Pharmaceutical Delivery Considering Cellular Metabolic Responses, Oxidative Stress and Cellular Longevity.Nanomaterials (Basel, Switzerland) · 2021Review
- siRNA Delivery Using Dithiocarbamate-Anchored Oligonucleotides on Gold Nanorods.Bioconjugate chemistry · 2019Article
- Engineering functional inorganic-organic hybrid systems: advances in siRNA therapeutics.Chemical Society reviews · 2018Review
- Gold nanorods/siRNA complex administration for knockdown of PARP-1: a potential treatment for perinatal asphyxia.International journal of nanomedicine · 2018Article
- Effect of the polyelectrolyte coating on the photothermal efficiency of gold nanorods and the photothermal induced cancer cell damage.IET nanobiotechnology · 2017Article
- Gold Nanotheranostics: Proof-of-Concept or Clinical Tool?Nanomaterials (Basel, Switzerland) · 2015Review
- Article
- Nanoparticles and the blood-brain barrier: advancing from in-vitro models towards therapeutic significance.Pharmaceutical research · 2015Review
- Nanotherapeutic approach for opiate addiction using DARPP-32 gene silencing in an animal model of opiate addiction.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2015Article
- Multifunctional gold nanorods for siRNA gene silencing and photothermal therapy.Advanced healthcare materials · 2014Article
- Topical delivery of siRNA into skin using SPACE-peptide carriers.Journal of controlled release : official journal of the Controlled Release Society · 2014Article
- Novel siRNA delivery strategy: a new "strand" in CNS translational medicine?Cellular and molecular life sciences : CMLS · 2014Review
- Facile Synthesis of PEGylated PLGA Nanoparticles Encapsulating Doxorubicin and its In Vitro Evaluation as Potent Drug Delivery Vehicle.Drug delivery and translational research · 2013Article
- Multifunctional gold nanoparticles for diagnosis and therapy of disease.Molecular pharmaceutics · 2013Review
- Multimodality imaging of RNA interference.Current medicinal chemistry · 2013Review
- Gold nanorods based platforms for light-mediated theranostics.Theranostics · 2013Review
- Increasing TNF levels solely in the rat hippocampus produces persistent pain-like symptoms.Pain · 2012Article
- Increased brain radioactivity by intranasal P-labeled siRNA dendriplexes within in situ-forming mucoadhesive gels.International journal of nanomedicine · 2012Article
- Image guided biodistribution and pharmacokinetic studies of theranostics.Theranostics · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
aimGold nanorods (GNRs), cellular imaging nanoprobes, have been used for drug delivery therapy to immunologically privileged regions in the brain. We demonstrate that nanoplexes formed by electrostatic binding between negatively charged RNA and positively charged GNRs, silence the expression of the target housekeeping gene, glyceraldehyde 3-phosphate dehydrogenase (GAPDH) within the CA1 hippocampal region of the rat brain, without showing cytotoxicity. MATERIALS &
methodsFluorescence imaging with siRNA(Cy3)GAPDH and dark-field imaging using plasmonic enhanced scattering from GNRs were used to monitor the distribution of the nanoplexes within different neuronal cell types present in the targeted hippocampal region. RESULTS &
conclusionOur results show robust nanoplex uptake and slow release of the fluorescent gene silencer with significant impact on the suppression of GAPDH gene expression (70% gene silencing, >10 days postinjection). The observed gene knockdown using nanoplexes in targeted regions of the brain opens a new era of drug treatment for neurological disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.