ArticleMycopathologia2011
Variation in genotype and higher virulence of a strain of Sporothrix schenckii causing disseminated cutaneous sporotrichosis.
Article in Mycopathologia, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 24 citations in OpenAlex.
- Epidemiology, Clinicopathological Features, Etiological Spectrum and Outcomes of Subcutaneous Mycoses: A 14-Year Retrospective Study.Journal of fungi (Basel, Switzerland) · 2026Article
- Disseminated subcutaneous sporotrichosis in an immunocompetent patient: A case report and a systematic literature review.Medical mycology case reports · 2025Article
- Cutaneous disseminated sporotrichosis associated with diabetes: A case report and literature review.PLoS neglected tropical diseases · 2023Review
- Oral treatment with 10% potassium iodide solution for refractory cutaneous-disseminated sporotrichosis in an immunocompetent adult: Case report.Frontiers in microbiology · 2022Article
- Sporotrichosis In Immunocompromised Hosts.Journal of fungi (Basel, Switzerland) · 2019Review
- Cutaneous Disseminated and Extracutaneous Sporotrichosis: Current Status of a Complex Disease.Journal of fungi (Basel, Switzerland) · 2017Review
- Molecular Components of the Sporothrix schenckii Complex that Induce Immune Response.Current microbiology · 2016Review
- Phenotypic and molecular identification of Sporothrix isolates of clinical origin in Northeast China.Mycopathologia · 2013Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sporotrichosis is usually a localized, lymphocutaneous disease, but its disseminated type was rarely reported. The main objective of this study was to identify specific DNA sequence variation and virulence of a strain of Sporothrix schenckii isolated from the lesion of disseminated cutaneous sporotrichosis. We confirmed this strain to be S. schenckii by(®) tubulin and chitin synthase gene sequence analysis in addition to the routine mycological and partial ITS and NTS sequencing. We found a 10-bp deletion in the ribosomal NTS region of this strain, in reference to the sequence of control strains isolated from fixed cutaneous sporotrichosis. After inoculated into immunosuppressed mice, this strain caused more extensive system involvement and showed stronger virulence than the control strain isolated from a fixed cutaneous sporotrichosis. Our study thus suggests that different clinical manifestation of sporotrichosis may be associated with variation in genotype and virulence of the strain, independent of effects due to the immune status of the host.
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