Trial reportEuropean journal of applied physiology2012
Passing the anaerobic threshold is associated with substantial changes in the gene expression profile in white blood cells.
Trial report in European journal of applied physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 48 citations in OpenAlex.
- Early Cardiac Dysfunction in Adolescents With Low Vigorous Physical Activity.Journal of the American Heart Association · 2025Trial
- Effect of Lower and Upper Body High Intensity Training on Genes Associated with Cellular Stress Response.BioMed research international · 2017Trial
- Cellular Stress Response Gene Expression During Upper and Lower Body High Intensity Exercises.PloS one · 2017Trial
- Differential Expression of Innate and Adaptive Immune Genes during Acute Physical Exercise in American Quarter Horses.Animals : an open access journal from MDPI · 2023Article
- Resistance exercise with different workloads have distinct effects on cellular respiration of peripheral blood mononuclear cells.Physiological reports · 2022Article
- Fra-2 overexpression upregulates pro-metastatic cell-adhesion molecules, promotes pulmonary metastasis, and reduces survival in a spontaneous xenograft model of human breast cancer.Journal of cancer research and clinical oncology · 2022Article
- Transcriptomic modulation in response to high-intensity interval training in monocytes of older women with type 2 diabetes.European journal of applied physiology · 2022Article
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- Protein O-GlcNAc Modification Increases in White Blood Cells After a Single Bout of Physical Exercise.Frontiers in immunology · 2018Article
- The Transcriptome of Type I Murine Astrocytes under Interferon-Gamma Exposure and Remyelination Stimulus.Molecules (Basel, Switzerland) · 2017Article
- Receptor Mincle promotes skin allergies and is capable of recognizing cholesterol sulfate.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Vitamin C, A and E supplementation decreases the expression of HSPA1A and HSPB1 genes in the leukocytes of young polish figure skaters during a 10-day training camp.Journal of the International Society of Sports Nutrition · 2015Article
- Investigation of manic and euthymic episodes identifies state- and trait-specific gene expression and STAB1 as a new candidate gene for bipolar disorder.Translational psychiatry · 2014Article
- Functional genomics in the study of mind-body therapies.Ochsner journal · 2014Review
- The status of and future research into Myalgic Encephalomyelitis and Chronic Fatigue Syndrome: the need of accurate diagnosis, objective assessment, and acknowledging biological and clinical subgroups.Frontiers in physiology · 2014Article
- Dynamically regulated miRNA-mRNA networks revealed by exercise.BMC physiology · 2013Article
- Effects of Exercise on Gene Expression of Inflammatory Markers in Human Peripheral Blood Cells: A Systematic Review.Current cardiovascular risk reportsReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
High and moderate intensity endurance exercise alters gene expression in human white blood cells (WBCs), but the understanding of how this effect occurs is limited. To increase our knowledge of the nature of this process, we investigated the effects of passing the anaerobic threshold (AnT) on the gene expression profile in WBCs of athletes. Nineteen highly trained skiers participated in a treadmill test with an incremental step protocol until exhaustion (ramp test to exhaustion, RTE). The average total time to exhaustion was 14:40 min and time after AnT was 4:50 min. Two weeks later, seven of these skiers participated in a moderate treadmill test (MT) at 80% peak O(2) uptake for 30 min, which was slightly below their AnTs. Blood samples were obtained before and immediately after both tests. RTE was associated with substantially greater leukocytosis and acidosis than MT. Gene expression in WBCs was measured using whole genome microarray expression analysis before and immediately after each test. A total of 310 upregulated genes were found after RTE, and 69 genes after MT of which 64 were identical to RTE. Both tests influenced a variety of known gene pathways related to inflammation, stress response, signal transduction and apoptosis. A large group of differentially expressed previously unknown small nucleolar RNA and small Cajal body RNA was found. In conclusion, a 15-min test to exhaustion was associated with substantially greater changes of gene expression than a 30-min test just below the AnT.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.