ArticleImmunologic research2011
Pneumocystis infection and the pathogenesis of chronic obstructive pulmonary disease.
Article in Immunologic research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 40 citations in OpenAlex.
- Journal of investigative medicine : the official publication of the American Federation for Clinical Research · 2017Trial
- Primaquine-Induced Methemoglobinemia: A Case Report.Cureus · 2025Article
- Microbial dysbiosis and the host airway epithelial response: insights into HIV-associated COPD using multi'omics profiling.Respiratory research · 2023Article
- Mortality Trends in Risk Conditions and Invasive Mycotic Disease in the United States, 1999-2018.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2022Article
- Review
- Inter-Specimen Imbalance of Mitochondrial Gene Copy Numbers Predicts Clustering ofJournal of fungi (Basel, Switzerland) · 2018Article
- Pneumocystis-Driven Inducible Bronchus-Associated Lymphoid Tissue Formation Requires Th2 and Th17 Immunity.Cell reports · 2017Article
- Pneumocystis infection alters the activation state of pulmonary macrophages.Immunobiology · 2017Article
- Detection of Pneumocystis jirovecii by Quantitative PCR To Differentiate Colonization and Pneumonia in Immunocompromised HIV-Positive and HIV-Negative Patients.Journal of clinical microbiology · 2016Article
- Lung Malignancies in HIV Infection.Seminars in respiratory and critical care medicine · 2016Review
- Article
- Emphysema Distribution and Diffusion Capacity Predict Emphysema Progression in Human Immunodeficiency Virus Infection.PloS one · 2016Article
- The changing face of asthma and its relation with microbes.Trends in microbiology · 2015Review
- Diagnosis of Pneumocystis jirovecii pneumonia in immunocompromised patients by real-time PCR: a 4-year prospective study.Journal of clinical microbiology · 2014Article
- Pneumocystis jirovecii can be productively cultured in differentiated CuFi-8 airway cells.mBio · 2014Article
- Aspergillus spp. colonization in exhaled breath condensate of lung cancer patients from Puglia Region of Italy.BMC pulmonary medicine · 2014Article
- Pneumocystis elicits a STAT6-dependent, strain-specific innate immune response and airway hyperresponsiveness.American journal of respiratory cell and molecular biology · 2012Article
- The emerging relationship between the airway microbiota and chronic respiratory disease: clinical implications.Expert review of respiratory medicine · 2011Review
- Thoracic diseases associated with HIV infection in the era of antiretroviral therapy: clinical and imaging findings.Radiographics : a review publication of the Radiological Society of North America, IncArticle
- Pathogenesis and management of emphysema in people with HIV.Expert review of respiratory medicineReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
With increases in the immunocompromised patient population and aging of the HIV+ population, the risk of serious fungal infections and their complications will continue to rise. In these populations, infection with the fungal opportunistic pathogen Pneumocystis jirovecii remains a leading cause of morbidity and mortality. Infection with Pneumocystis (Pc) has been shown to be associated with the development of chronic obstructive pulmonary disease (COPD) in human subjects with and without HIV infection and in non-human primate models of HIV infection. In human studies and in a primate model of HIV/Pc co-infection, we have shown that antibody response to the Pc protein, kexin (KEX1), correlates with protection from colonization, Pc pneumonia, and COPD. These findings support the hypothesis that immunity to KEX1 may be critical to controlling Pc colonization and preventing or slowing development of COPD.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.