Evidence map›Paper›PMID 21717066›Full record

ReviewImmunologic research2011

Latent tuberculosis: what the host "sees"?

Hannah P Gideon, JoAnne L Flynn

Abstract readReview
In one paragraph

Review in Immunologic research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 99 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
99citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

99 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Immunogenicity and Safety of the M72/AS01Frontiers in immunology · 2019
    Pooled it
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Review
  10. GC/MS Analysis and Protective Effects ofPlants (Basel, Switzerland) · 2024
    Article
  11. Article
  12. Host Cell Death and Modulation of Immune Response againstInternational journal of molecular sciences · 2024
    Review
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Review
  20. Article

39 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Hannah P GideonDepartment of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, W1144 Biomedical Science Tower, Pittsburgh, PA 15261, USA.
JoAnne L Flynn

Funding

CD4 T Cells in TuberculosisR01AI050732 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FLYNN, JOANNE L. · 2002 to 2013
$4.8M
Defining how the spectrum of latency affects reactivation of TBR01HL106804 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FLYNN, JOANNE L., KIRSCHNER, DENISE E · 2010 to 2013
$2.6M
A Multi-scale and Multi-system Approach to Understand Granuloma Formation in TBR33HL092883 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FLYNN, JOANNE L. · 2008 to 2010
$672k
NHLBI NIH HHS HL092883NHLBI NIH HHS HL106804NHLBI NIH HHS R01 HL106804NHLBI NIH HHS R33 HL092883NIAID NIH HHS AI50732NIAID NIH HHS R01 AI050732
6 · The paper itself

Abstract

Mycobacterium tuberculosis (MTB), the causative agent of tuberculosis (TB), is the most successful pathogen of mankind and remains a major threat to global health as the leading cause of death due to a bacterial pathogen. Yet 90-95% of those who are infected with MTB remain otherwise healthy. These people are classified as "latently infected," but remain a reservoir from which active TB cases will continue to develop ("reactivation tuberculosis"). Latent infection is defined by the absence of clinical symptoms of TB in addition to a delayed hypersensitivity reaction to the purified protein derivative of MTB used in tuberculin skin test or a T-cell response to MTB-specific antigens. In the absence of reliable control measures for tuberculosis, understanding latent MTB infection and subsequent reactivation is a research priority. This review aims to summarize the recent findings in human and non-human primate models of tuberculosis that have led to new concepts of latent tuberculosis.

Indexed as

AnimalsBiomarkersDisease Models, AnimalGranulomaHost-Pathogen InteractionsHumansImmunity, CellularImmunity, HumoralLatent TuberculosisMycobacterium tuberculosisPrimatesT-LymphocytesBiomarkers

Identifiers

PMID21717066
PMCPMC3788603

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.