ArticleMolecular biology reports2012
Different genetic patterns in avian Toll-like receptor (TLR)5 genes.
Article in Molecular biology reports, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 21 citations in OpenAlex.
- Characterisation and functional analysis of canine TLR5.Innate immunity · 2020Article
- Avian Toll-like receptor allelic diversity far exceeds human polymorphism: an insight from domestic chicken breeds.Scientific reports · 2018Article
- Lack of diversity at innate immunity Toll-like receptor genes in the Critically Endangered White-winged Flufftail (Sarothrura ayresi).Scientific reports · 2016Article
- Molecular tools to support metabolic and immune function research in the Guinea Fowl (Numida meleagris).BMC genomics · 2015Article
- Characterisation of Toll-like receptors 4, 5 and 7 and their genetic variation in the grey partridge.Genetica · 2015Article
- Polymorphisms of chicken TLR3 and 7 in different breeds.PloS one · 2015Article
- Protein evolution of Toll-like receptors 4, 5 and 7 within Galloanserae birds.Genetics, selection, evolution : GSE · 2014Article
- Expression profiles of Toll-like receptors 1, 2 and 5 in selected organs of commercial and indigenous chickens.Journal of applied genetics · 2013Article
- Innate sensing of viruses by pattern recognition receptors in birds.Veterinary research · 2013Review
- Expression analysis of turkey (Meleagris gallopavo) toll-like receptors and molecular characterization of avian specific TLR15.Molecular biology reports · 2012Article
- Variation at innate immunity Toll-like receptor genes in a bottlenecked population of a New Zealand robin.PloS one · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Toll-like receptors (TLRs) mediate immune response via recognition of pathogen-associated molecular patterns (PAMPs), thus play important roles in host defense. Polymorphisms of TLR5 may affect their recognition of bacterial flagellin, leading to varied host resistance to pathogenic infections. Here, we cloned TLR5 genes from Common Pheasant, Guinea fowl and 9 Chicken breeds and analyzed their sequences. The open reading frames of TLR5 were sequenced. Amino acid analysis indicated that TLR5 from Chicken breeds shared 99.4-99.9% homology. The amino acid homology of TLR5 ranged from 92.1 to 92.5% between Chickens and Guinea fowl, 95.7-96.1% between Chickens and Turkey, 94.3-94.7% between Chickens and Common Pheasant, and 79.9-80.1% between Chickens and Zebra-finch. Different genetic patterns were determined among Chickens, Common Pheasant, Guinea fowl, Turkey and Zebra-finch. It was found that there were 92 amino acid polymorphic sites, among which 5 sites in chicken TLR5, 63 sites in Guinea fowl TLR5 and 44 sites in Common Pheasant TLR5. Our data indicate that the positive Darwinian selection occurred in avian TLR5 genes since frequency of non-synonymous (d ( N )) > frequency of synonymous (d ( S )). These results also demonstrate that avian TLR5 genes are polymorphic among avian breeds, suggesting a varied resistance among breeds of avian. This information might be of help to improve the health of avian by breeding and vaccination.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.