ArticleFrontiers in microbiology2011
The Role of the spv Genes in Salmonella Pathogenesis.
Article in Frontiers in microbiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 125 papers, 1 of them a synthesis that pooled it.
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Who cites it
125 citing papers in PubMed, 1 synthesis or guideline pooled it, 209 citations in OpenAlex.
- Combatting Salmonella: a focus on antimicrobial resistance and the need for effective vaccination.BMC infectious diseases · 2025Pooled it
- Disseminated multidrug-resistant Salmonella enterica serovar Dublin infection associated with plasmid-borne CMY-2 gene in a patient with travel to a farm in Mexico.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026Article
- Public health data collected by PulseNet support a role forMicrobiology spectrum · 2026Article
- MAP4Ks drive cell death in response tomBio · 2026Article
- The role of synbiotic in controlling Salmonella infection in broilers.Scientific reports · 2026Article
- Genomic characterization of a virulent multidrug-resistant Salmonella enterica serovar Enteritidis strain isolated from meat rabbits (Oryctolagus cuniculus) in China.BMC microbiology · 2026Article
- The renaissance ofFrontiers in immunology · 2026Review
- Genomic and transcriptomic analyses reveal a Gifsy-1 prophage-encoded virulence module associated with enhanced epithelial adhesion ofFrontiers in cellular and infection microbiology · 2026Article
- Genomic Insights into Antimicrobial Resistance and Virulence of MonophasicMicroorganisms · 2025Article
- Molecular characterization of Salmonella isolates from poultry in Egypt: Detection of virulence, ESBLs genes and antimicrobial resistance profiling.Veterinary research communications · 2025Article
- Salmonella multimutants enable efficient identification of SPI-2 effector protein function in gut inflammation and systemic colonization.Nature communications · 2025Article
- Control of Salmonella in poultry: The role of host immunity and vaccines.Poultry science · 2025Review
- Salmonella stress response systems as targets for anti-virulence strategies.BMC microbiology · 2025Article
- Non-typhoidal Salmonella transmission reservoirs in Sub-Saharan Africa: a genomic assessment from a one health perspective.Antimicrobial resistance and infection control · 2025Article
- Whole-genome sequencing-based characterization of Salmonella enterica Serovar Enteritidis and Kentucky isolated from laying hens in northwest of Iran, 2022-2023.Gut pathogens · 2025Article
- Towards decentralization ofFrontiers in microbiology · 2025Article
- Comprehensive epidemiological profiling of poultry-derivedFrontiers in microbiology · 2025Article
- Genetic engineering ofEcoSal Plus · 2024Review
- Outbreak of Esophagitis and Ingluvitis Caused byVeterinary sciences · 2024Article
- Serovars, virulence factors, and antimicrobial resistance profile of non-typhoidal Salmonella in the human-dairy interface in Northwest Ethiopia: A one health approach.PLoS neglected tropical diseases · 2024Article
65 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Salmonella strains cause three main types of diseases in people: gastroenteritis, enteric (typhoid) fever, and non-typhoid extra-intestinal disease with bacteremia. Genetic analysis indicates that each clinical syndrome requires distinct sets of virulence genes, and Salmonella isolates differ in their constellation of virulence traits. The spv locus is strongly associated with strains that cause non-typhoid bacteremia, but are not present in typhoid strains. The spv region contains three genes required for the virulence phenotype in mice: the positive transcriptional regulator spvR and two structural genes spvB and spvC. SpvB and SpvC are translocated into the host cell by the Salmonella pathogenicity island-2 type-three secretion system. SpvB prevents actin polymerization by ADP-ribosylation of actin monomers, while SpvC has phosphothreonine lyase activity and has been shown to inhibit MAP kinase signaling. The exact mechanisms by which SpvB and SpvC act in concert to enhance virulence are still unclear. SpvB exhibits a cytotoxic effect on host cells and is required for delayed cell death by apoptosis following intracellular infection. Strains isolated from systemic infections of immune compromised patients, particularly HIV patients, usually carry the spv locus, strongly suggesting that CD4 T cells are required to control disease due to Salmonella that are spv positive. This association is not seen with typhoid fever, indicating that the pathogenesis and immunology of typhoid have fundamental differences from the syndrome of non-typhoid bacteremia.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.