ArticleStem cells international2011
Human motor neuron progenitor transplantation leads to endogenous neuronal sparing in 3 models of motor neuron loss.
Article in Stem cells international, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 61 citations in OpenAlex.
- Alleviation of mutant TDP-43-mediated neuropathology by inducible stem cells in monkeys.International journal of biological sciences · 2026Article
- Transplantation of Neural Precursors Derived from Induced Pluripotent Cells Preserve Perineuronal Nets and Stimulate Neural Plasticity in ALS Rats.International journal of molecular sciences · 2020Article
- Article
- Deconstructing Neurogenesis, Transplantation and Genome-Editing as Neural Repair Strategies in Brain Disease.Frontiers in cell and developmental biology · 2020Review
- Neuroprotection: Pro-survival and Anti-neurotoxic Mechanisms as Therapeutic Strategies in Neurodegeneration.Frontiers in cellular neuroscience · 2019Review
- Article
- Restoring Motor Neurons in Spinal Cord Injury With Induced Pluripotent Stem Cells.Frontiers in cellular neuroscience · 2019Review
- Advances, challenges and future directions for stem cell therapy in amyotrophic lateral sclerosis.Molecular neurodegeneration · 2017Review
- Induced Pluripotent Stem Cell Therapies for Cervical Spinal Cord Injury.International journal of molecular sciences · 2016Review
- Developing therapies for spinal muscular atrophy.Annals of the New York Academy of Sciences · 2016Review
- The Paradoxical Signals of Two TrkC Receptor Isoforms Supports a Rationale for Novel Therapeutic Strategies in ALS.PloS one · 2016Article
- Stem cell therapy for amyotrophic lateral sclerosis.Cell regeneration (London, England) · 2015Article
- Intrathecal delivery of mesenchymal stromal cells protects the structure of altered perineuronal nets in SOD1 rats and amends the course of ALS.Stem cells (Dayton, Ohio) · 2014Article
- Stem cell transplantation for amyotrophic lateral sclerosis: therapeutic potential and perspectives on clinical translation.Cellular and molecular life sciences : CMLS · 2014Review
- Electrical stimulation of transplanted motoneurons improves motor unit formation.Journal of neurophysiology · 2014Article
- Molecular, genetic and stem cell-mediated therapeutic strategies for spinal muscular atrophy (SMA).Journal of cellular and molecular medicine · 2014Review
- Human mesenchymal cells from adipose tissue deposit laminin and promote regeneration of injured spinal cord in rats.PloS one · 2014Article
- Electrical stimulation of embryonic neurons for 1 hour improves axon regeneration and the number of reinnervated muscles that function.Journal of neuropathology and experimental neurology · 2013Article
- Transplantation of gene-corrected motor neurons as a therapeutic strategy for spinal muscular atrophy.Molecular therapy : the journal of the American Society of Gene Therapy · 2013Article
- Neural progenitors derived from human induced pluripotent stem cells survive and differentiate upon transplantation into a rat model of amyotrophic lateral sclerosis.Stem cells translational medicine · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Motor neuron loss is characteristic of many neurodegenerative disorders and results in rapid loss of muscle control, paralysis, and eventual death in severe cases. In order to investigate the neurotrophic effects of a motor neuron lineage graft, we transplanted human embryonic stem cell-derived motor neuron progenitors (hMNPs) and examined their histopathological effect in three animal models of motor neuron loss. Specifically, we transplanted hMNPs into rodent models of SMA (Δ7SMN), ALS (SOD1 G93A), and spinal cord injury (SCI). The transplanted cells survived and differentiated in all models. In addition, we have also found that hMNPs secrete physiologically active growth factors in vivo, including NGF and NT-3, which significantly enhanced the number of spared endogenous neurons in all three animal models. The ability to maintain dying motor neurons by delivering motor neuron-specific neurotrophic support represents a powerful treatment strategy for diseases characterized by motor neuron loss.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.