ArticlePharmacognosy magazine2011
Sodium metabisulfite-induced polymerization of sickle cell hemoglobin incubated in the extracts of three medicinal plants (Anacardium occidentale, Psidium guajava, and Terminalia catappa).
Article in Pharmacognosy magazine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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11 citing papers in PubMed, 30 citations in OpenAlex.
- Review
- Rapid measurement of hemoglobin-oxygen dissociation by leveraging Bohr effect and Soret band bathochromic shift.The Analyst · 2024Article
- ATR1 Angiotensin II Receptor Reduces Hemoglobin S Polymerization, Phosphatidylserine Exposure, and Increases Deformability of Sickle Cell Disease Erythrocytes.Cell biochemistry and biophysics · 2022Article
- A portable impedance microflow cytometer for measuring cellular response to hypoxia.Biotechnology and bioengineering · 2021Article
- Smartphone-based sickle cell disease detection and monitoring for point-of-care settings.Biosensors & bioelectronics · 2020Article
- Rational Drug Design of Peptide-Based Therapies for Sickle Cell Disease.Molecules (Basel, Switzerland) · 2019Review
- Protective Effect of Cashew Gum (Anacardium occidentale L.) on 5-Fluorouracil-Induced Intestinal Mucositis.Pharmaceuticals (Basel, Switzerland) · 2019Article
- Hypoxia-enhanced adhesion of red blood cells in microscale flow.Microcirculation (New York, N.Y. : 1994) · 2017Article
- The in vitro antisickling and antioxidant effects of aqueous extracts Zanthoxyllum heitzii on sickle cell disorder.BMC complementary and alternative medicine · 2013Article
- Search for antisickling agents from plants.Pharmacognosy reviews · 2013Article
- Comparative hypoglycemic activities of aqueous and ethanolic extracts of four medicinal plants (Acanthus montanus, Asystasia gangetica, Emilia coccinea and Hibiscus rosasinensis) in Type I diabetic rats.Journal of intercultural ethnopharmacologyArticle
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1 author at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundThe exploitation and utilization of vast varieties of herbal extracts may serve as alternative measures to deter aggregation of deoxygenated sickle cell hemoglobin (deoxyHbS) molecules.
objectiveThe present in vitro study ascertained the capacity of three medicinal plants, namely, Anacardium occidentale, Psidium guajava, and Terminalia catappa, to alter polymerization of HbS. MATERIALS AND
methodsSpectrophotometric method was used to monitor the level of polymerization of hemolysate HbS molecules treated with sodium metabisulfite (Na(2) S(2) O(5)) at a regular interval of 30 s for a period of 180 s in the presence of separate aqueous extracts of A. occidentale, P. guajava, and T. catappa. At time intervals of 30 s, the level of polymerization was expressed as percentage of absorbance relative to the control sample at the 180th s.
resultsAlthough extracts of the three medicinal plants caused significant (P < 0.05) reduction in polymerization of deoxyHbS molecules, the corresponding capacity in this regard diminished with increase in incubation time. Aqueous extract of P. guajava exhibited the highest capacity to reduced polymerization of deoxyHbS molecules. Whereas at t > 60 s, extract concentration of 400 mg% of A. occidentale activated polymerization of deoxyHbS molecules by 6.23±1.34, 14.53±1.67, 21.15±1.89, and 24.42±1.09%, 800 mg% of T. catappa at t > 30 s gave values of 2.50±1.93, 5.09±1.96, 10.00±0.99, 15.38±1.33, and 17.31±0.97%.
conclusionThe capacity of the three medicinal plants to interfere with polymerization of deoxyHbS molecules depended on the duration of incubation and concentration of the extracts.
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