ArticleThe ISME journal2012
De novo metagenomic assembly reveals abundant novel major lineage of Archaea in hypersaline microbial communities.
Article in The ISME journal, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 190 papers.
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Who cites it
190 citing papers in PubMed.
- Metagenomic insights into the taxonomic and metabolic diversity of the microbiome of Lake Karum in the Danakil Depression, Ethiopia.Environmental microbiome · 2026Article
- Multilayered Human Activities Shape the Microbial Communities of Groundwater-Dependent Ecosystems on an Arid Oceanic Island.Microbial ecology · 2026Article
- New lineages provide insights into the convergent evolution of extreme salt adaptation within symbiotic Archaea.Molecular biology and evolution · 2026Article
- Unveiling a Microbial Treasure Trove: Phylogenetic Diversity and Bioremediation Potential in a High-Altitude Andean Saline System.Microbial ecology · 2026Article
- Methanoperedenaceae archaea: a 20-year research journey.Nature communications · 2026Review
- Horizontal gene transfer and gene loss drove the divergent evolution of host dependency in Micrarchaeota.National science review · 2026Article
- A genomic view of Earth's biomes.Nature reviews. Genetics · 2026Review
- Biogeography and host interactions of CPR and DPANN viruses in acid mine drainage sediments.Nature communications · 2025Article
- Prior knowledge on context-driven DNA fragmentation probabilities can improve de novo genome assembly algorithms.BMC bioinformatics · 2025Article
- DPANN Archaea and CPR Bacteria: insights into early cellular evolution?Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025Review
- Phylogenomic analyses indicate the archaeal superphylum DPANN originated from free-living euryarchaeal-like ancestors.Nature microbiology · 2025Article
- Candidatus List No. 6.International journal of systematic and evolutionary microbiology · 2025Article
- Revealing the Prokaryotic Microbial Community Structures and their Ecological Potentials in Manjanggul Cave, a Lava Tube on Jeju Island.Current microbiology · 2025Article
- Article
- First Insights Into the Biological and Physical-Chemical Diversity of Various Salt Ponds of Trapani, Sicily.Environmental microbiology reports · 2025Article
- Unveiling the life of archaea in sediments: Diversity, metabolic potentials, and ecological roles.iMetaOmics · 2025Review
- Cyanobacterial mats and their associated microbiomes in saline and freshwater lakes from the Bolivian Altiplano.Frontiers in microbiology · 2025Article
- Integrating genomic evidence for an updated taxonomy of the bacterial genus Spiribacter.Scientific reports · 2024Article
- Extremely acidic proteomes and metabolic flexibility in bacteria and highly diversified archaea thriving in geothermal chaotropic brines.Nature ecology & evolution · 2024Article
- Unique Features of Extremely Halophilic Microbiota Inhabiting Solar Saltworks Fields of Vietnam.Microorganisms · 2024Article
130 more citing papers are in PubMed but not listed here.
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9 authors.
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Abstract
This study describes reconstruction of two highly unusual archaeal genomes by de novo metagenomic assembly of multiple, deeply sequenced libraries from surface waters of Lake Tyrrell (LT), a hypersaline lake in NW Victoria, Australia. Lineage-specific probes were designed using the assembled genomes to visualize these novel archaea, which were highly abundant in the 0.1-0.8 μm size fraction of lake water samples. Gene content and inferred metabolic capabilities were highly dissimilar to all previously identified hypersaline microbial species. Distinctive characteristics included unique amino acid composition, absence of Gvp gas vesicle proteins, atypical archaeal metabolic pathways and unusually small cell size (approximately 0.6 μm diameter). Multi-locus phylogenetic analyses demonstrated that these organisms belong to a new major euryarchaeal lineage, distantly related to halophilic archaea of class Halobacteria. Consistent with these findings, we propose creation of a new archaeal class, provisionally named 'Nanohaloarchaea'. In addition to their high abundance in LT surface waters, we report the prevalence of Nanohaloarchaea in other hypersaline environments worldwide. The simultaneous discovery and genome sequencing of a novel yet ubiquitous lineage of uncultivated microorganisms demonstrates that even historically well-characterized environments can reveal unexpected diversity when analyzed by metagenomics, and advances our understanding of the ecology of hypersaline environments and the evolutionary history of the archaea.
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