ArticleCell death & disease2011
Diverse system stresses: common mechanisms of chromosome fragmentation.
Article in Cell death & disease, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed.
- Tracking Karyotype Changes in Treatment-Induced Drug-Resistant Evolution.Methods in molecular biology (Clifton, N.J.) · 2024Article
- The Importance of Monitoring Non-clonal Chromosome Aberrations (NCCAs) in Cancer Research.Methods in molecular biology (Clifton, N.J.) · 2024Article
- The New Era of Cancer Cytogenetics and Cytogenomics.Methods in molecular biology (Clifton, N.J.) · 2024Article
- ATR inhibition overcomes platinum tolerance associated with ERCC1- and p53-deficiency by inducing replication catastrophe.NAR cancer · 2023Article
- Article
- CRISPRthripsis: The Risk of CRISPR/Cas9-induced Chromothripsis in Gene Therapy.Stem cells translational medicine · 2022Article
- Insight into the Molecular Basis Underlying Chromothripsis.International journal of molecular sciences · 2022Review
- Chimeric chromosome landscapes of human somatic cell cultures show dependence on stress and regulation of genomic repeats by CGGBP1.Oncotarget · 2022Article
- Chromothripsis-Explosion in Genetic Science.Cells · 2021Review
- ER Stress and Micronuclei Cluster: Stress Response Contributes to Genome Chaos in Cancer.Frontiers in cell and developmental biology · 2021Article
- Therapy Induced Genome Chaos: A Novel Mechanism of Rapid Cancer Drug Resistance.Frontiers in cell and developmental biology · 2021Article
- Article
- A comparison of particulate hexavalent chromium cytotoxicity and genotoxicity in human and leatherback sea turtle lung cells from a one environmental health perspective.Toxicology and applied pharmacology · 2019Article
- Article
- What Is Karyotype Coding and Why Is Genomic Topology Important for Cancer and Evolution?Frontiers in genetics · 2019Review
- Health and Disease-Emergent States Resulting From Adaptive Social and Biological Network Interactions.Frontiers in medicine · 2019Article
- A Postgenomic Perspective on Molecular Cytogenetics.Current genomics · 2018Article
- Understanding aneuploidy in cancer through the lens of system inheritance, fuzzy inheritance and emergence of new genome systems.Molecular cytogenetics · 2018Review
- There are only four basic modes of cell death, although there are many ad-hoc variants adapted to different situations.Cell & bioscience · 2018Review
- Classifying the evolutionary and ecological features of neoplasms.Nature reviews. Cancer · 2017Review
Corrections and comments
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Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chromosome fragmentation (C-Frag) is a newly identified MCD (mitotic cell death), distinct from apoptosis and MC (mitotic catastrophe). As different molecular mechanisms can induce C-Frag, we hypothesize that the general mechanism of its induction is a system response to cellular stress. A clear link between C-Frag and diverse system stresses generated from an array of molecular mechanisms is shown. Centrosome amplification, which is also linked to diverse mechanisms of stress, is shown to occur in association with C-Frag. This led to a new model showing that diverse stresses induce common, MCD. Specifically, different cellular stresses target the integral chromosomal machinery, leading to system instability and triggering of MCD by C-Frag. This model of stress-induced cell death is also applicable to other types of cell death. The current study solves the previously confusing relationship between the diverse molecular mechanisms of chromosome pulverization, suggesting that incomplete C-Frag could serve as the initial event responsible for forms of genome chaos including chromothripsis. In addition, multiple cell death types are shown to coexist with C-Frag and it is more dominant than apoptosis at lower drug concentrations. Together, this study suggests that cell death is a diverse group of highly heterogeneous events that are linked to stress-induced system instability and evolutionary potential.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.