ArticleAIDS (London, England)2011
Cervical HIV-1 RNA shedding after cryotherapy among HIV-positive women with cervical intraepithelial neoplasia stage 2 or 3.
Article in AIDS (London, England), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 25 citations in OpenAlex.
- Side effects and acceptability measures for thermal ablation as a treatment for cervical precancer in low-income and middle-income countries: a systematic review and meta-synthesis.Family medicine and community health · 2022Pooled it
- Safety of intrauterine devices among women with HIV: a systematic review.Contraception · 2016Pooled it
- Thermal ablation versus cryotherapy or loop excision to treat women positive for cervical precancer on visual inspection with acetic acid test: pilot phase of a randomised controlled trial.The Lancet. Oncology · 2020Trial
- Trial
- Association of cervical biopsy with HIV type 1 genital shedding among women on highly active antiretroviral therapy.AIDS research and human retroviruses · 2013Trial
- HPV Screening in Women Living with HIV (WLHIV) in Karnataka, India: Can it be Integrated into ART Centres?Asian Pacific journal of cancer prevention : APJCP · 2025Article
- Human Immunodeficiency Virus Type 1 RNA Genital Tract Shedding After Cryotherapy for Cervical Intraepithelial Neoplasia in Western Kenya.Open forum infectious diseases · 2023Article
- Increased Cervical Human Immunodeficiency Virus (HIV) RNA Shedding Among HIV-Infected Women Randomized to Loop Electrosurgical Excision Procedure Compared to Cryotherapy for Cervical Intraepithelial Neoplasia 2/3.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2018Article
- Cost-effectiveness of cervical cancer screening and preventative cryotherapy at an HIV treatment clinic in Kenya.Cost effectiveness and resource allocation : C/E · 2017Article
- Accuracy of visual inspection with acetic acid to detect cervical cancer precursors among HIV-infected women in Kenya.International journal of cancer · 2015Article
- Past and future of prophylactic ablation of the cervical squamocolumnar junction.Ecancermedicalscience · 2015Article
- Residual disease and HPV persistence after cryotherapy for cervical intraepithelial neoplasia grade 2/3 in HIV-positive women in Kenya.PloS one · 2014Article
- Clustering patterns of human papillomavirus infections among HIV-positive women in Kenya.Infectious agents and cancer · 2013Article
- Comparison of HPV DNA testing in cervical exfoliated cells and tissue biopsies among HIV-positive women in Kenya.International journal of cancer · 2013Article
- Impact of loop electrosurgical excision procedure for cervical intraepithelial neoplasia on HIV-1 genital shedding: a prospective cohort study.BJOG : an international journal of obstetrics and gynaecology · 2013Article
- Prevalence and determinants of human papillomavirus infection and cervical lesions in HIV-positive women in Kenya.British journal of cancer · 2012Article
- Cervical cancer prevention in low- and middle-income countries: feasible, affordable, essential.Cancer prevention research (Philadelphia, Pa.) · 2012Review
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 3 countries.
Funding
Abstract
objectiveTo determine the effect of cryotherapy on HIV-1 cervical shedding.
designProspective cohort study.
methodsFive hundred HIV-positive women enrolled at an HIV treatment clinic in Nairobi, Kenya were screened for cervical cancer. Women diagnosed with cervical intraepithelial neoplasia stage 2 or 3 (CIN 2/3) by histology were offered cryotherapy treatment. The first 50 women had cervical swabs taken at baseline and at 2 and 4 weeks following treatment. Swabs were analyzed for HIV-1 RNA and compared using General Estimating Equation (GEE) with binomial or Gaussian links.
resultsOf the 50 women enrolled, 40 were receiving antiretroviral therapy (ART) and 10 were not receiving ART at the time of cryotherapy and during study follow-up. Among all women, the odds of detectable cervical HIV-1 RNA did not increase at 2 weeks [odds ratio (OR) 1.18; 95% confidence interval (CI) 0.65-2.13] or 4 weeks (OR 1.29; 95% CI 0.71-2.33) following cryotherapy. Among 10 women not receiving ART, the OR of detectable shedding at 2 weeks was higher, but not statistically significant (OR 4.02; 95% CI 0.53-30.79; P = 0.2), and at 4 weeks remained unchanged (OR 1.00; 95% CI 0.27-3.74).
conclusionThere was no increase in detectable cervical HIV-1 RNA among HIV-positive women after cryotherapy. The risk of HIV-1 transmission after cryotherapy may not be significant, particularly among women already on ART at the time of cervical treatment. However, further investigation is needed among women not receiving ART.
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