ArticleThe Journal of nervous and mental disease2011
Toxoplasma gondii seropositivity and suicide rates in women.
Article in The Journal of nervous and mental disease, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
56 citing papers in PubMed, 3 syntheses or guidelines pooled it, 152 citations in OpenAlex.
- Association of T. gondii infection with suicide: a systematic review and meta-analysis.BMC public health · 2020Pooled it
- A systematic review and meta-analysis of the seroprevalence of Toxoplasma gondii in cats in mainland China.Parasites & vectors · 2017Pooled it
- A meta-analysis of the prevalence of Toxoplasma gondii in animals and humans in Ethiopia.Parasites & vectors · 2015Pooled it
- Epidemiological aspects and inflammatory cytokine profiles associated with Toxoplasma gondii infection in suicide attempters in Iran.BMC infectious diseases · 2025Article
- Impact ofJournal of clinical medicine · 2024Review
- Article
- Toxoplasma gondii infection of the central nervous system and suicide: A case-control study of decedents.European journal of microbiology & immunology · 2023Article
- Suicide and Inflammation.Advances in experimental medicine and biology · 2023Article
- Is latent Toxoplasma gondii infection associated with the occurrence of schizophrenia? A case-control study.PloS one · 2022Article
- Prevalence and Predictors ofFrontiers in psychiatry · 2022Article
- Comprehensive Overview ofPathogens (Basel, Switzerland) · 2021Review
- Association betweenPathogens (Basel, Switzerland) · 2021Article
- Association between Suicide andPathogens (Basel, Switzerland) · 2021Article
- Article
- Association betweenPathogens (Basel, Switzerland) · 2021Article
- Article
- Neurological and Neurobehavioral Disorders Associated withJournal of parasitology research · 2021Review
- Review
- Lipophilic vs. hydrophilic statins and psychiatric hospitalizations and emergency room visits in US Veterans with schizophrenia and bipolar disorder.Pteridines · 2021Article
- Exposure to common infections and risk of suicide and self-harm: a longitudinal general population study.European archives of psychiatry and clinical neuroscience · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
Abstract
Toxoplasma gondii (T. gondii) is an intracellular protozoan parasite that infects roughly a third of the world population. In an immunocompetent host, infection is generally chronic and asymptomatic, as the immune system keeps T. gondii confined to cysts and the intracellular space within the muscle and brain. Seropositivity has been linked to schizophrenia, car accidents, changes in personality, and more recently, suicidal attempts. Very recently, seroprevalence for 20 European countries was found to be associated with increased suicide rates. Although suicide rates were age-standardized, given that T. gondii seroprevalence increases with age and that the blood samples were drawn in women, we now retested in women only the association between suicide and T. gondii seropositivity, stratified by age. Simple correlations between ranked T. gondii seropositivity and suicide rate identified statistically significant relationships in women 60 years or older (p < 0.05); adjusting for GDP, the statistical significance expanded to include women 45 years and older. The strongest association was in the 60- to 74-year-old group where, after adjustment for GDP, the relationship (p = 0.007) resisted Bonferroni adjustment for multiple comparisons. In conclusion, the results suggest that a positive relationship between rates of infection with T. gondii and suicide is apparent in women of postmenopausal age. Prospective studies are necessary to further confirm this association predictively and to explore mechanisms mediating this relationship.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.