SynthesisNeurology2011
Genetic associations with brain microbleeds: Systematic review and meta-analyses.
Synthesis in Neurology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 35 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 3 syntheses or guidelines pooled it, 68 citations in OpenAlex.
- Cortical superficial siderosis and bleeding risk in cerebral amyloid angiopathy: A meta-analysis.Neurology · 2019Pooled it
- Pooled it
- APOE genotype and MRI markers of cerebrovascular disease: systematic review and meta-analysis.Neurology · 2013Pooled it
- Cross-trait genetic architecture of intracerebral hemorrhage highlights convergent vascular, hematologic and lipid pathways.Metabolism open · 2026Article
- Hemorrhage Pattern and Amyloid Burden in Cerebral Amyloid Angiopathy.Journal of the American Heart Association · 2026Article
- APOE ε2 is associated with reduced risk of early post-stroke cognitive impairment but not with long-term functional outcome.BMC neurology · 2025Article
- Multifaceted roles of APOE in Alzheimer disease.Nature reviews. Neurology · 2024Review
- A comprehensive analysis of APOE genotype effects on human brain structure in the UK Biobank.Translational psychiatry · 2024Article
- Genetics of common cerebral small vessel disease.Nature reviews. Neurology · 2022Review
- Cerebrospinal fluid biomarkers and apolipoprotein E genotype in cerebral amyloid angiopathy. A narrative review.Cerebral circulation - cognition and behavior · 2021Review
- Review
- Association of common genetic variants with brain microbleeds: A genome-wide association study.Neurology · 2020Article
- Emerging insights from the genetics of cerebral small-vessel disease.Annals of the New York Academy of Sciences · 2020Review
- Genome-Wide Association Study of Cerebral Microbleeds on MRI.Neurotoxicity research · 2020Article
- Review
- Associations of Pulse and Blood Pressure with Hippocampal Volume by APOE and Cognitive Phenotype: The Alzheimer's Disease Neuroimaging Initiative (ADNI).Dementia and geriatric cognitive disorders · 2018Article
- Update on Vascular Cognitive Impairment Associated with Subcortical Small-Vessel Disease.Journal of Alzheimer's disease : JAD · 2018Review
- Background and distribution of lobar microbleeds in cognitive dysfunction.Brain and behavior · 2017Article
- Incident risk and progression of cerebral microbleeds in healthy adults: a multi-occasion longitudinal study.Neurobiology of aging · 2017Article
- Cerebral microbleeds and risk of incident dementia: the Framingham Heart Study.Neurobiology of aging · 2017Article
Corrections and comments
- Erratum issued
Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
objectiveWe performed a systematic review and meta-analyses to assess the evidence for genetic associations with brain microbleeds (BMBs).
methodsWe sought all published studies of the association between any genetic polymorphism and BMBs studied in a total of >100 people. We critically appraised studies, and calculated pooled odds ratios (ORs) using the generic inverse variance fixed effects method. We used I² and χ² statistics to assess heterogeneity, and fail-safe N estimates to assess the robustness of our results.
resultsOnly the APOE ε2/3/4 polymorphism had been studied in >100 people (10 studies, 7,351 participants). Compared with people with the ε3/ε3 genotype, carriers of the ε4 allele (ε4+) were statistically significantly more likely to have BMBs in any location (ε4+ vs ε3/ε3: pooled OR 1.22, 95% confidence interval [CI] 1.05-1.41, p = 0.01). For strictly lobar BMBs, this association appeared slightly stronger (ε4+ vs ε3/ε3: pooled OR 1.35, 95% CI 1.10-1.66, p = 0.005). The association of ε4+ genotypes with strictly lobar BMBs was reasonably robust to potential publication and reporting biases.
conclusionsGiven the known associations of APOE alleles with lobar intracerebral hemorrhage and cerebral amyloid angiopathy, these findings support the concept that strictly lobar BMBs may be an imaging biomarker of cerebral amyloid angiopathy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.