ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2011
Postnatal development of intrinsic and synaptic properties transforms signaling in the layer 5 excitatory neural network of the visual cortex.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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31 citing papers in PubMed, 53 citations in OpenAlex.
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- Electrophysiology and morphology of human cortical supragranular pyramidal cells in a wide age range.eLife · 2025Article
- Satellite microglia: marker of traumatic brain injury and regulator of neuronal excitability.Journal of neuroinflammation · 2025Article
- Electrophysiology and Morphology of Human Cortical Supragranular Pyramidal Cells in a Wide Age Range.bioRxiv : the preprint server for biology · 2025Article
- Postnatal development of electrophysiological and morphological properties in layer 2/3 and layer 5 pyramidal neurons in the mouse primary visual cortex.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Electrophysiological properties of layer 2/3 pyramidal neurons in the primary visual cortex of a retinitis pigmentosa mouse model (Frontiers in cellular neuroscience · 2023Article
- Developmental depression-to-facilitation shift controls excitation-inhibition balance.Communications biology · 2022Article
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- Refinement of Active and Passive Membrane Properties of Layer V Pyramidal Neurons in Rat Primary Motor Cortex During Postnatal Development.Frontiers in molecular neuroscience · 2021Article
- Polynomial, piecewise-Linear, Step (PLS): A Simple, Scalable, and Efficient Framework for Modeling Neurons.Frontiers in neuroinformatics · 2021Article
- Brainstem development requires galactosylceramidase and is critical for pathogenesis in a model of Krabbe disease.Nature communications · 2020Article
- Progressive alignment of inhibitory and excitatory delay may drive a rapid developmental switch in cortical network dynamics.Journal of neurophysiology · 2020Article
- Visual Experience Regulates the Intrinsic Excitability of Visual Cortical Neurons to Maintain Sensory Function.Cell reports · 2019Article
- Unique Maturation Trajectories of Basket and Chandelier Cells in the Neocortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Developmental Emergence of Sparse Coding: A Dynamic Systems Approach.Scientific reports · 2017Article
- Article
- Development of Activity in the Mouse Visual Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
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2 authors at 2 institutions in 2 countries.
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Abstract
Information flow in neocortical circuits is regulated by two key parameters: intrinsic neuronal properties and the short-term activity-dependent plasticity of synaptic transmission. Using multineuronal whole-cell voltage recordings, we characterized the postnatal maturation of the electrophysiological properties and short-term plasticity of excitatory synaptic transmission between pairs of layer 5 (L5) pyramidal neurons (n = 158) in acute slices of rat visual cortex over the first postnatal month. We found that the intrinsic and synaptic properties of L5 pyramidal neurons develop in parallel. Before postnatal day 15 (P15), intrinsic electrophysiological properties were tuned to low-frequency operation, characterized by high apparent input resistance, a long membrane time constant, and prolonged somatic action potentials. Unitary excitatory synaptic potentials were of large amplitude (P11-P15; median, 514 μV), but showed pronounced use-dependent depression during prolonged regular and physiologically relevant presynaptic action potential firing patterns. In contrast, in mature animals we observed a developmental decline of the peak amplitude of unitary EPSPs (P25-P29; median, 175 μV) paralleled by a decrease in apparent input resistance, membrane time constant, and somatic action potential duration. Notably, synaptic signaling of complex action potential firing patterns was also transformed, with P25-P29 connections faithfully signaling action potential trains at frequencies up to 40 Hz (1st to 50th action potential ratio, 0.91 ± 0.12). Postnatal refinement of intrinsic properties and short-term plasticity therefore transforms the capacity of the L5 excitatory neural network of the visual cortex to generate and process patterns of action potential firing and contribute to network activity.
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