ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2011
Theta-modulated head direction cells in the rat anterior thalamus.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers.
What it found
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Who cites it
76 citing papers in PubMed, 153 citations in OpenAlex.
- Dorsoventral gradient of theta sweeps in the medial entorhinal cortex.Science advances · 2026Article
- Path Integration in Alzheimer's Disease: Orientation, Movement, and Theta Rhythmicity.Annual review of neuroscience · 2026Review
- Pathological tau alters head direction signaling and induces spatial disorientation.Cell reports · 2025Article
- Distinct subnetworks of the mouse anterior thalamic nuclei.Nature communications · 2025Article
- Unsupervised Phenotyping Reveals Disrupted Neural Firing Characteristics in the Anterior Thalamus and Surrounding Brain Regions Following Third-Trimester Equivalent Alcohol Exposure in Mice.bioRxiv : the preprint server for biology · 2025Article
- Phase Precession Relative to Turning Angle in Theta-Modulated Head Direction Cells.Hippocampus · 2025Article
- A systems model of alternating theta sweeps via firing rate adaptation.Current biology : CB · 2025Article
- Novelty triggers time-dependent theta oscillatory dynamics in cortical-hippocampal-midbrain circuitry.Molecular brain · 2024Article
- Intrinsic Bipolar Head-Direction Cells in the Medial Entorhinal Cortex.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Comparison of head direction cell firing characteristics across thalamo-parahippocampal circuitry.Hippocampus · 2024Article
- The Anterior Thalamus Preferentially Drives Allocentric But Not Egocentric Orientation Tuning in Postrhinal Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Interactions between rodent visual and spatial systems during navigation.Nature reviews. Neuroscience · 2023Review
- Convergence of location, direction, and theta in the rat anteroventral thalamic nucleus.iScience · 2023Article
- Article
- Neuromodulation of the anterior thalamus: Current approaches and opportunities for the future.Current research in neurobiology · 2023Review
- Flexible cue anchoring strategies enable stable head direction coding in both sighted and blind animals.Nature communications · 2022Article
- Macroscale connections of the mouse lateral preoptic area and anterior lateral hypothalamic area.The Journal of comparative neurology · 2022Article
- Time to retire the serial Papez circuit: Implications for space, memory, and attention.Neuroscience and biobehavioral reviews · 2022Review
- The anterior thalamic nuclei: core components of a tripartite episodic memory system.Nature reviews. Neuroscience · 2022Review
- Running speed and REM sleep control two distinct modes of rapid interhemispheric communication.Cell reports · 2022Article
16 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 3 countries.
Funding
Abstract
A major tool in understanding how the brain processes information is the analysis of neuronal output at each hierarchical level along the pathway of signal propagation. Theta rhythm and head directionality are the two main signals found across all levels of Papez's circuit, which supports episodic memory formation. Here, we provide evidence that the functional interaction between both signals occurs at a subcortical level. We show that there is population of head direction cells (39%) in rat anteroventral thalamic nucleus that exhibit rhythmic spiking in the theta range. This class of units, termed HD-by-theta (head direction-by-theta) cells, discharged predominantly in spike trains at theta frequency (6-12 Hz). The highest degree of theta rhythmicity was evident when the animal was heading/facing in the preferred direction, expressed by the Gaussian peak of the directional tuning curve. The theta-rhythmic mode of spiking was closely related to the firing activity of local theta-bursting cells. We also found that 32% of anteroventral theta-bursting cells displayed a head-directional modulation of their spiking. This crossover between theta and head-directional signals indicates that anterior thalamus integrates information related to heading and movement, and may therefore actively modulate hippocampo-dencephalic information processing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.