ArticleCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology2011
Nonsteroidal anti-inflammatory drug and acetaminophen use and risk of adult myeloid leukemia.
Article in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Associations between aspirin use and the risk of cancers: a meta-analysis of observational studies.BMC cancer · 2018Pooled it
- Novel NSAID Analogs Exhibit Anti-Leukemic Activity Through Modulation of Apoptotic and Survival Pathways.International journal of molecular sciences · 2026Article
- Divergent gene expression ofFrontiers in oncology · 2025Article
- Obesity and Leukemia: Biological Mechanisms, Perspectives, and Challenges.Current obesity reports · 2024Review
- Predicted leukocyte telomere length and risk of myeloid neoplasms.Human molecular genetics · 2023Article
- The Effects of Biologics on Hematologic Malignancy Development in Patients with Ankylosing Spondylitis, Psoriasis, or Psoriatic Arthritis: A National Cohort Study.Biomedicines · 2023Article
- The association between non-steroidal anti-inflammatory drugs (NSAIDs) and myelodysplastic syndromes in the Adults in Minnesota with Myelodysplastic Syndromes (AIMMS) Study.Leukemia & lymphoma · 2021Article
- Paracetamol Intake and Hematologic Malignancies: A Meta-Analysis of Observational Studies.Journal of clinical medicine · 2021Review
- Sepsis and Risk of Cancer Among Elderly Adults in the United States.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2019Article
- NSAID consumption and risk of acute myeloid leukemia: a national population-based case-control study.Cancer management and research · 2018Article
- Chemical exposures and risk of acute myeloid leukemia and myelodysplastic syndromes in a population-based study.International journal of cancer · 2017Article
- Obesity over the life course and risk of acute myeloid leukemia and myelodysplastic syndromes.Cancer epidemiology · 2016Article
- Chemopreventive Effects of Dietary Eicosapentaenoic Acid Supplementation in Experimental Myeloid Leukemia.Cancer prevention research (Philadelphia, Pa.) · 2015Article
- Prostate cancer risk and nonsteroidal antiinflammatory drug use in the Finnish prostate cancer screening trial.British journal of cancer · 2014Article
- Rapamycin combined with celecoxib enhanced antitumor effects of mono treatment on chronic myelogenous leukemia cells through downregulating mTOR pathway.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Article
- Frontline therapy of AML: should the older patient be treated differently?Current hematologic malignancy reports · 2014Review
- Anthropometric, medical history and lifestyle risk factors for myeloproliferative neoplasms in the Iowa Women's Health Study cohort.International journal of cancer · 2014Article
- Non-steroidal anti-inflammatory drugs use is associated with reduced risk of inflammation-associated cancers: NIH-AARP study.PloS one · 2014Article
- Exogenous hormone use, reproductive history and risk of adult myeloid leukaemia.British journal of cancer · 2013Article
- The influence of Cox-2 and bioactive lipids on hematological cancers.Current angiogenesis · 2013Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundLittle is known about the causes of adult leukemia. A few small studies have reported a reduced risk associated with regular use of nonsteroidal anti-inflammatory drugs (NSAID).
methodsIn a population-based case-control study, we evaluated analgesic use among 670 newly diagnosed myeloid leukemia cases [including 420 acute myeloid leukemias (AML) and 186 chronic myeloid leukemias (CML)] and 701 controls aged 20 to 79 years. Prior use of aspirin, ibuprofen, acetaminophen, other NSAIDs, and COX-2 inhibitors was assessed and included frequency, duration, and quantity. ORs and 95% CIs were calculated using unconditional logistic regression adjusting for potential confounders.
resultsRegular/extra strength aspirin use was inversely associated with myeloid leukemia in women (OR = 0.59, 95% CI = 0.37-0.93) but not in men (OR = 0.85, 95% CI = 0.58-1.24). In contrast, acetaminophen use was associated with an increased risk of myeloid leukemia in women only (OR = 1.60, 95% CI = 1.04-2.47). These relationships were stronger with increasing dose and duration. When stratified by leukemia type, aspirin use was inversely associated with AML and CML in women. No significant overall associations were found with ibuprofen or COX-2 inhibitors for either sex; however, a decreased risk was observed with other anti-inflammatory analgesic use for women with AML or CML (OR = 0.47, 95% CI = 0.22-0.99; OR = 0.31, 95% CI = 0.10-0.92, respectively).
conclusionsOur results provide additional support for the chemopreventive benefits of NSAIDs, at least in women. Because leukemia ranks fifth in person-years of life lost due to malignancy, further investigation is warranted. IMPACT: NSAIDs may reduce, whereas acetaminophen may increase, myeloid leukemia risk in women.
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