ArticleGenes & development2011
Nitric oxide coordinates metabolism, growth, and development via the nuclear receptor E75.
Article in Genes & development, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers.
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Who cites it
79 citing papers in PubMed, 139 citations in OpenAlex.
- Multi-omics reveals an ecdysone-activated Eip75B-FABP signaling axis coordinating nutrient metabolism for development in Hermetia illucens.Journal of advanced research · 2026Article
- Genetic and Molecular Regulation of Ecdysone Biosynthesis During Insect Metamorphosis.Insects · 2026Review
- Low-Dose HGlobal challenges (Hoboken, NJ) · 2026Article
- HR3/RORα-mediated cholesterol sensing regulates TOR signaling.Nature communications · 2026Article
- Endocrine Control of Lipid Metabolism.Advances in experimental medicine and biology · 2026Review
- Transcriptomic Characterization of miRNAs inGenes · 2025Article
- A wrinkle in timers: evolutionary rewiring of conserved biological timekeepers.Trends in biochemical sciences · 2025Review
- Article
- Nutritional condition drives spatial variation in physiology of Antarctic lipid-storing copepods.Ecology and evolution · 2024Article
- Developmental analysis of Spalt function in the Drosophila prothoracic gland.Development (Cambridge, England) · 2024Article
- Ecdysone-controlled nuclear receptor ERR regulates metabolic homeostasis in the disease vector mosquito Aedes aegypti.PLoS genetics · 2024Article
- Function and regulation of nitric oxide signaling in Drosophila.Molecules and cells · 2024Review
- Genetic variation in chromatin state across multiple tissues in Drosophila melanogaster.PLoS genetics · 2023Article
- Functional Characterization of the Nuclear Receptor GeneInsects · 2023Article
- Drosophila postembryonic nervous system development: a model for the endocrine control of development.Genetics · 2023Review
- A Single Nucleotide Variant in the PPARγ-homolog Eip75B Affects Fecundity in Drosophila.Molecular biology and evolution · 2023Article
- A critical role for ecdysone response genes in regulating egg production in adult female Rhodnius prolixus.PloS one · 2023Article
- Nitric oxide-soluble guanylyl cyclase pathway as a contributor to age-related memory impairment in Drosophila.Aging cell · 2022Article
- Regulation of protein function and degradation by heme, heme responsive motifs, and CO.Critical reviews in biochemistry and molecular biology · 2022Review
- Transcriptional Regulators of Ecdysteroid Biosynthetic Enzymes and Their Roles in Insect Development.Frontiers in physiology · 2022Review
19 more citing papers are in PubMed but not listed here.
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nitric oxide gas acts as a short-range signaling molecule in a vast array of important physiological processes, many of which include major changes in gene expression. How these genomic responses are induced, however, is poorly understood. Here, using genetic and chemical manipulations, we show that nitric oxide is produced in the Drosophila prothoracic gland, where it acts via the nuclear receptor ecdysone-induced protein 75 (E75), reversing its ability to interfere with its heterodimer partner, Drosophila hormone receptor 3 (DHR3). Manipulation of these interactions leads to gross alterations in feeding behavior, fat deposition, and developmental timing. These neuroendocrine interactions and consequences appear to be conserved in vertebrates.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.