Trial reportDiabetes care2011
Improved pharmacokinetic and pharmacodynamic profile of rapid-acting insulin using needle-free jet injection technology.
Trial report in Diabetes care, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 31 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Pharmacology of Rapid-acting Insulin Injected by Needle-free Jet-injection in Patients With Diabetes
Reproducibility of Insulin Action When Administered by Needle-free Jet Injection
Pharmacokinetic and Pharmacodynamic Profile of Insulin Lispro Using Needle-Free Jet Injection Technology
Who cites it
31 citing papers in PubMed, 2 syntheses or guidelines pooled it, 79 citations in OpenAlex.
- Short-acting insulin analogues versus regular human insulin for adult, non-pregnant persons with type 2 diabetes mellitus.The Cochrane database of systematic reviews · 2018Pooled it
- Short-acting insulin analogues versus regular human insulin for adults with type 1 diabetes mellitus.The Cochrane database of systematic reviews · 2016Pooled it
- Effect of needle-free injection on psychological insulin resistance and insulin dosage in patients with type 2 diabetes.Frontiers in endocrinology · 2024Trial
- A clinical observation study on the effect of needle-free insulin syringe on blood glucose control and well-being index in patients with early-onset type 2 diabetes mellitus.Frontiers in endocrinology · 2023Trial
- The Absorption of Needle-Free Insulin Aspart Through Jet Injector in Different Body Parts of Healthy Individuals.Frontiers in endocrinology · 2022Trial
- Pharmacokinetic and Pharmacodynamic Variability of Insulin When Administered by Jet Injection.Journal of diabetes science and technology · 2017Trial
- Comparison of jet injector and insulin pen in controlling plasma glucose and insulin concentrations in type 2 diabetic patients.Medicine · 2017Trial
- Improved Insulin Pharmacokinetics Using a Novel Microneedle Device for Intradermal Delivery in Patients with Type 2 Diabetes.Diabetes technology & therapeutics · 2016Trial
- Improved Postprandial Glucose Control Using the InsuPad Device in Insulin-Treated Type 2 Diabetes: Injection Site Warming to Improve Glycemic Control.Journal of diabetes science and technology · 2015Trial
- Needle-free jet injection of rapid-acting insulin improves early postprandial glucose control in patients with diabetes.Diabetes care · 2013Trial
- Enhanced absorption of insulin aspart as the result of a dispersed injection strategy tested in a randomized trial in type 1 diabetic patients.Diabetes care · 2013Trial
- Pharmacokinetics and postprandial glycemic excursions following insulin lispro delivered by intradermal microneedle or subcutaneous infusion.Journal of diabetes science and technology · 2012Trial
- Insulin Injection Behaviors and Association with Glycemic Outcomes in Patients with Diabetes: A Real-World Survey in Spain.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2026Article
- Advances in Insulin Delivery: Transdermal and Needle-Free Technologies as Emerging Strategies to Improve Metabolic Control and Treatment Adherence.Life (Basel, Switzerland) · 2026Review
- New Technologies for Blood Glucose Management in Elderly Diabetics: An Interpretation of theAging medicine (Milton (N.S.W)) · 2025Review
- Perioperative Pain Management for Mastectomy in Dogs: A Narrative Review.Animals : an open access journal from MDPI · 2025Review
- Numerical study on the supersonic gas-solid two-phase injection mechanism of needle-free syringe.PloS one · 2025Article
- Article
- Surgical Site Infiltration with Comfort-in Device and Traditional Syringe in Dogs Undergoing Regional Mastectomy: Evaluation of Intra- and Postoperative Pain and Oxidative Stress.Animals : an open access journal from MDPI · 2024Article
- Determining Losses in Jet Injection Subcutaneous Insulin Delivery: A Model-Based Approach.Journal of diabetes science and technology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveInsulin administered by jet injectors is dispensed over a larger subcutaneous area than insulin injected with a syringe, which may facilitate a more rapid absorption. This study compared the pharmacologic profile of administration of insulin aspart by jet injection to that by conventional insulin pen. RESEARCH DESIGN AND
methodsEuglycemic glucose clamp tests were performed in 18 healthy volunteers after subcutaneous administration of 0.2 units/kg body wt of aspart, either administered by jet injection or by conventional pen, using a randomized, double-blind, double-dummy, cross over study design. Pharmacodynamic and pharmacokinetic profiles were derived from the glucose infusion rate (GIR) needed to maintain euglycemia and from plasma insulin levels, respectively.
resultsThe time to maximal GIR was significantly shorter when insulin was injected with the jet injector compared with conventional pen administration (51 ± 3 vs. 105 ± 11 min, P < 0.0001). The time to peak insulin concentration was similarly reduced (31 ± 3 vs. 64 ± 6 min, P < 0.0001) and peak insulin concentrations were increased (108 ± 13 vs. 79 ± 7 mU/L, P = 0.01) when insulin was injected by jet injection compared with conventional pen injection. Jet injector insulin administration reduced the time to 50% glucose disposal by ∼40 min (P < 0.0001). There were no differences in maximal GIR, total insulin absorption, or total insulin action between the two devices.
conclusionsAdministration of insulin aspart by jet injection enhances insulin absorption and reduces the duration of glucose-lowering action. This profile resembles more closely the pattern of endogenous insulin secretion and may help to achieve better meal insulin coverage and correction of postprandial glucose excursions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.