ArticleNucleic acids research2011
Translation-competent 48S complex formation on HCV IRES requires the RNA-binding protein NSAP1.
Article in Nucleic acids research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Polypyrimidine-Tract-Binding Protein Isoforms Differentially Regulate the Hepatitis C Virus Internal Ribosome Entry Site.Viruses · 2022Article
- Review
- Ribosomal Protein S6: A Potential Therapeutic Target against Cancer?International journal of molecular sciences · 2021Review
- Cellular factors involved in the hepatitis C virus life cycle.World journal of gastroenterology · 2021Review
- Hepatitis C Virus Translation Regulation.International journal of molecular sciences · 2020Review
- eIF2A, an initiator tRNA carrier refractory to eIF2α kinases, functions synergistically with eIF5B.Cellular and molecular life sciences : CMLS · 2018Article
- RNA binding protein 24 regulates the translation and replication of hepatitis C virus.Protein & cell · 2018Article
- The GAIT translational control system.Wiley interdisciplinary reviews. RNA · 2018Review
- The bent conformation of poly(A)-binding protein induced by RNA-binding is required for its translational activation function.RNA biology · 2017Article
- Translational upregulation of Aurora-A by hnRNP Q1 contributes to cell proliferation and tumorigenesis in colorectal cancer.Cell death & disease · 2017Article
- Integrative gene network analysis identifies key signatures, intrinsic networks and host factors for influenza virus A infections.NPJ systems biology and applications · 2017Article
- cis-Acting RNA elements in the hepatitis C virus RNA genome.Virus research · 2015Review
- Review
- Inhibition of hepatitis C virus in chimeric mice by short synthetic hairpin RNAs: sequence analysis of surviving virus shows added selective pressure of combination therapy.Journal of virology · 2014Article
- AUF1 contributes to Cryptochrome1 mRNA degradation and rhythmic translation.Nucleic acids research · 2014Article
- Establishment of chronic hepatitis C virus infection: translational evasion of oxidative defence.World journal of gastroenterology · 2014Review
- Article
- RNA-binding proteins impacting on internal initiation of translation.International journal of molecular sciences · 2013Review
- Control of translation and miRNA-dependent repression by a novel poly(A) binding protein, hnRNP-Q.PLoS biology · 2013Article
- Heterotrimeric GAIT complex drives transcript-selective translation inhibition in murine macrophages.Molecular and cellular biology · 2012Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Translation of many cellular and viral mRNAs is directed by internal ribosomal entry sites (IRESs). Several proteins that enhance IRES activity through interactions with IRES elements have been discovered. However, the molecular basis for the IRES-activating function of the IRES-binding proteins remains unknown. Here, we report that NS1-associated protein 1 (NSAP1), which augments several cellular and viral IRES activities, enhances hepatitis C viral (HCV) IRES function by facilitating the formation of translation-competent 48S ribosome-mRNA complex. NSAP1, which is associated with the solvent side of the 40S ribosomal subunit, enhances 80S complex formation through correct positioning of HCV mRNA on the 40S ribosomal subunit. NSAP1 seems to accomplish this positioning function by directly binding to both a specific site in the mRNA downstream of the initiation codon and a 40S ribosomal protein (or proteins).
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