ArticleBlood2011
Adult human circulating CD34⁻Lin⁻CD45⁻CD133⁻ cells can differentiate into hematopoietic and endothelial cells.
Article in Blood, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 26 citations in OpenAlex.
- Trial
- Circulating CD133+/–CD34– Have Increased c-Turkish journal of haematology : official journal of Turkish Society of Haematology · 2023Article
- Review
- An update of circulating rare cell types in healthy adult peripheral blood: findings of immature erythroid precursors.Annals of translational medicine · 2018Article
- Advances in rare cell isolation: an optimization and evaluation study.Journal of translational medicine · 2017Article
- Learning from Mother Nature: Innovative Tools to Boost Endogenous Repair of Critical or Difficult-to-Heal Large Tissue Defects.Frontiers in bioengineering and biotechnology · 2017Review
- Cultured circulating tumor cells and their derived xenografts for personalized oncology.Asian journal of urology · 2016Review
- In Vitro Endothelialization of Biodegradable Vascular Grafts Via Endothelial Progenitor Cell Seeding and Maturation in a Tubular Perfusion System Bioreactor.Tissue engineering. Part C, Methods · 2016Article
- Mesenchymal Stem and Progenitor Cells in Normal and Dysplastic Hematopoiesis-Masters of Survival and Clonality?International journal of molecular sciences · 2016Review
- Identification of a New Cell Population Constitutively Circulating in Healthy Conditions and Endowed with a Homing Ability Toward Injured Sites.Scientific reports · 2015Article
- Aggf1 acts at the top of the genetic regulatory hierarchy in specification of hemangioblasts in zebrafish.Blood · 2014Article
- Cross talk with hematopoietic cells regulates the endothelial progenitor cell differentiation of CD34 positive cells.PloS one · 2014Article
- Human adipose tissue contains erythroid progenitors expressing fetal hemoglobin.World journal of stem cells · 2013Article
- Strategies and techniques to enhance the in situ endothelialization of small-diameter biodegradable polymeric vascular grafts.Tissue engineering. Part B, Reviews · 2013Review
- Specific marking of hESCs-derived hematopoietic lineage by WAS-promoter driven lentiviral vectors.PloS one · 2012Article
Corrections and comments
- Erratum issued
Authors and funding
10 authors at 8 institutions in 2 countries.
Funding
Abstract
A precise identification of adult human hemangioblast is still lacking. To identify circulating precursors having the developmental potential of the hemangioblast, we established a new ex vivo long-term culture model supporting the differentiation of both hematopoietic and endothelial cell lineages. We identified from peripheral blood a population lacking the expression of CD34, lineage markers, CD45 and CD133 (CD34⁻Lin⁻CD45⁻CD133⁻ cells), endowed with the ability to differentiate after a 6-week culture into both hematopoietic and endothelial lineages. The bilineage potential of CD34⁻Lin⁻CD45⁻CD133⁻ cells was determined at the single-cell level in vitro and was confirmed by transplantation into NOD/SCID mice. In vivo, CD34⁻Lin⁻CD45⁻CD133⁻ cells showed the ability to reconstitute hematopoietic tissue and to generate functional endothelial cells that contribute to new vessel formation during tumor angiogenesis. Molecular characterization of CD34⁻Lin⁻D45⁻CD133⁻ cells unveiled a stem cell profile compatible with both hematopoietic and endothelial potentials, characterized by the expression of c-Kit and CXCR4 as well as EphB4, EphB2, and ephrinB2. Further molecular and functional characterization of CD34⁻Lin⁻CD45⁻CD133⁻ cells will help dissect their physiologic role in blood and blood vessel maintenance and repair in adult life.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.