Evidence map›Paper›PMID 21715295›Full record

ArticlePsychosomatic medicine

Posttraumatic stress disorder in anorexia nervosa.

Mae Lynn Reyes-Rodríguez, Ann Von Holle, Teresa Frances Ulman, Laura M Thornton, Kelly L Klump, Harry Brandt, Steve Crawford, Manfred M Fichter, Katherine A Halmi, Thomas Huber and 10 more

Registry-linked trialOpen access · greenAbstract read
In one paragraph

Article in Psychosomatic medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03156959 (Efficacy of Eye Movement Desensitization and Reprocessing), which is not on this map. Cited by 38 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 1 pooled it
6.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03156959 naunknown statusnot on this map

Efficacy of Eye Movement Desensitization and Reprocessing (EMDR) Plus Broad Form of Enhanced Cognitive Behavioural Therapy (CBT-Eb) in Patients With Eating Disorders. A Randomized Controlled Trial

TypeinterventionalSponsorRuggeri, MirellaRan2017 to 2022Enrolled80ConditionsEating DisorderArmsEMDR, CBT-Eb
3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 1 synthesis or guideline pooled it, 100 citations in OpenAlex.

  1. Pooled it
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  9. Higher arterial stiffness and blunted vagal control of the heart in young women with compared to without a clinical diagnosis of PTSD.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 12 institutions in 3 countries.

Mae Lynn Reyes-RodríguezDepartment of Psychiatry, University of North Carolina at Chapel Hill, 101 Manning Drive, CB #7160, Chapel Hill, NC 27599-7160, USA.
Ann Von Holle
Teresa Frances Ulman
Laura M Thornton
Kelly L Klump
Harry Brandt
Steve Crawford
Manfred M Fichter
Katherine A Halmi
Thomas Huber
Craig Johnson
Ian Jones
Allan S Kaplan
James E Mitchell
Michael Strober
Janet Treasure
D Blake Woodside
Wade H Berrettini
Walter H Kaye
Cynthia M Bulik
University of Maryland, Baltimore · USUniversity of North Carolina at Chapel Hill · USCalifornia University of Pennsylvania · USCornell University · USMedical Research Council · GBMichigan State University · USThe Recovery Center · USUniversity Health Network · CAUniversity of California, Los Angeles · USUniversity of California San Diego · USUniversity of North Dakota · USUniversity of Toronto · CA

Funding

Neurobiology of Feeding &Other Behaviors in BulimiaR01MH042984 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KAYE, WALTER H · 1988 to 2013
$6.3M
Monoamine Contributions to Neurocircuitry in Eating DisordersR01MH092793 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BAILER, URSULA FRANZISKA, KAYE, WALTER H · 2011 to 2015
$3.6M
Genetics of Anorexia NervosaR01MH066122 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KAYE, WALTER H · 2002 to 2006
$3.1M
Postdoctoral Research Training in Eating DisordersT32MH076694 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BULIK, CYNTHIA M · 2007 to 2016
$1.8M
Genetics of Anorexia NervosaR01MH066117 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DEVLIN, BERNIE · 2002 to 2006
$1.0M
UCAN: Uniting Couples (in the treatment of) Anorexia NervosaR01MH082732 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BAUCOM, DONALD H, BULIK, CYNTHIA M · 2007 to 2009
$919k
Engaging Latino Families in Eating Disorders TreatmentK23MH087954 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI REYES-RODRIGUEZ, MAE LYNN · 2010 to 2014
$747k
NIMH NIH HHS 3R01MH082732NIMH NIH HHS K23 MH087954NIMH NIH HHS K23-MH087954NIMH NIH HHS MH 66117NIMH NIH HHS R01 MH042984NIMH NIH HHS R01 MH066117NIMH NIH HHS R01 MH066122NIMH NIH HHS R01 MH082732NIMH NIH HHS R01 MH092793NIMH NIH HHS T32 MH076694
6 · The paper itself

Abstract

objectivesComorbidity among eating disorders, traumatic events, and posttraumatic stress disorder (PTSD) has been reported in several studies. The main objectives of this study were to describe the nature of traumatic events experienced and to explore the relationship between PTSD and anorexia nervosa (AN) in a sample of women.

methodsEight hundred twenty-four participants from the National Institutes of Health-funded Genetics of Anorexia Nervosa Collaborative Study were assessed for eating disorders, PTSD, and personality characteristics.

resultsFrom a final sample of 753 women with AN, 13.7% (n = 103) met Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, criteria for PTSD. The sample mean age was 29.5 (standard deviation = 11.1) years. In pairwise comparisons across AN subtypes, the odds of having a PTSD diagnosis were significantly lower in individuals with restricting AN than individuals with purging AN without binge eating (odds ratio = 0.49, 95% confidence interval = 0.30-0.80). Most participants with PTSD reported the first traumatic event before the onset of AN (64.1%, n = 66). The most common traumatic events reported by those with a PTSD diagnosis were sexually related traumas during childhood (40.8%) and during adulthood (35.0%).

conclusionsAN and PTSD do co-occur, and traumatic events tend to occur before the onset of AN. Clinically, these results underscore the importance of assessing trauma history and PTSD in individuals with AN and raise the question of whether specific modifications or augmentations to standard treatment for AN should be considered in a subgroup to address PTSD-related psychopathology.

Indexed as

AdolescentAdultAge FactorsAnorexia NervosaBody Mass IndexChildChild Abuse, SexualComorbidityDiagnostic and Statistical Manual of Mental DisordersEpigenomicsFemaleGenetic Predisposition to DiseaseHumansLife Change EventsMaleMenarche

Identifiers

PMID21715295
PMCPMC3132652
OpenAlexW1971529993

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.