ArticleNeurogastroenterology and motility2011
High-resolution spatial analysis of slow wave initiation and conduction in porcine gastric dysrhythmia.
Article in Neurogastroenterology and motility, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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45 citing papers in PubMed, 79 citations in OpenAlex.
- Electromechanical coupling across the gastroduodenal junction.Acta physiologica (Oxford, England) · 2025Review
- Simultaneous optical imaging of gastric slow waves and contractions in the in vivo porcine stomach.American journal of physiology. Gastrointestinal and liver physiology · 2024Article
- Transplanted ENSCs form functional connections with intestinal smooth muscle and restore colonic motility in nNOS-deficient mice.Stem cell research & therapy · 2023Article
- In vivo experimental validation of detection of gastric slow waves using a flexible multichannel electrogastrography sensor linear array.Biomedical engineering online · 2022Article
- Clinical application and research progress of extracellular slow wave recording in the gastrointestinal tract.World journal of gastrointestinal surgery · 2022Review
- Biomechanical constitutive modeling of the gastrointestinal tissues: a systematic review.Materials & design · 2022Article
- Targeted ablation of gastric pacemaker sites to modulate patterns of bioelectrical slow wave activation and propagation in an anesthetized pig model.American journal of physiology. Gastrointestinal and liver physiology · 2022Article
- Engaging biological oscillators through second messenger pathways permits emergence of a robust gastric slow-wave during peristalsis.PLoS computational biology · 2021Article
- Gastric ablation as a novel technique for modulating electrical conduction in the in vivo stomach.American journal of physiology. Gastrointestinal and liver physiology · 2021Article
- Strategies to Refine Gastric Stimulation and Pacing Protocols: Experimental and Modeling Approaches.Frontiers in neuroscience · 2021Review
- High-resolution Mapping of Hyperglycemia-induced Gastric Slow Wave Dysrhythmias.Journal of neurogastroenterology and motility · 2019Article
- Temporary Gastric Stimulation in Patients With Gastroparesis Symptoms: Low-Resolution Mapping Multiple Versus Single Mucosal Lead Electrograms.Gastroenterology research · 2019Article
- A Miniature Configurable Wireless System for Recording Gastric Electrophysiological Activity and Delivering High-Energy Electrical Stimulation.IEEE journal on emerging and selected topics in circuits and systems · 2018Article
- High-resolution electrical mapping of porcine gastric slow-wave propagation from the mucosal surface.Neurogastroenterology and motility · 2017Article
- Time-Delay Mapping of High-Resolution Gastric Slow-Wave Activity.IEEE transactions on bio-medical engineering · 2017Article
- A novel retractable laparoscopic device for mapping gastrointestinal slow wave propagation patterns.Surgical endoscopy · 2017Article
- Functional physiology of the human terminal antrum defined by high-resolution electrical mapping and computational modeling.American journal of physiology. Gastrointestinal and liver physiology · 2016Article
- Simultaneous anterior and posterior serosal mapping of gastric slow-wave dysrhythmias induced by vasopressin.Experimental physiology · 2016Article
- Characterization of Electrophysiological Propagation by Multichannel Sensors.IEEE transactions on bio-medical engineering · 2016Article
- Electrophysiological Mechanisms of Gastrointestinal Arrhythmogenesis: Lessons from the Heart.Frontiers in physiology · 2016Review
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Authors and funding
7 authors at 2 institutions in 3 countries.
Funding
Abstract
backgroundThe significance of gastric dysrhythmias remains uncertain. Progress requires a better understanding of dysrhythmic behaviors, including the slow wave patterns that accompany or promote them. The aim of this study was to use high-resolution spatiotemporal mapping to characterize and quantify the initiation and conduction of porcine gastric dysrhythmias.
methodsHigh-resolution mapping was performed on healthy fasted weaner pigs under general anesthesia. Recordings were made from the gastric serosa using flexible arrays (160-192 electrodes; 7.6mm spacing). Dysrhythmias were observed to occur in 14 of 97 individual recordings (from 8 of 16 pigs), and these events were characterized, quantified and classified using isochronal mapping and animation. KEY
resultsAll observed dysrhythmias originated in the corpus and fundus. The range of dysrhythmias included incomplete conduction block (n=3 pigs; 3.9±0.5cpm; normal range: 3.2±0.2cpm) complete conduction block (n=3; 3.7±0.4cpm), escape rhythm (n=5; 2.0±0.3cpm), competing ectopic pacemakers (n=5, 3.7±0.1cpm) and functional re-entry (n=3, 4.1±0.4cpm). Incomplete conduction block was observed to self-perpetuate due to retrograde propagation of wave fragments. Functional re-entry occurred in the corpus around a line of unidirectional block. 'Double potentials' were observed in electrograms at sites of re-entry and at wave collisions. CONCLUSIONS & INFERENCES: Intraoperative multi-electrode mapping of fasted weaner healthy pigs detected dysrhythmias in 15% of recordings (from 50% of animals), including patterns not previously reported. The techniques and findings described here offer new opportunities to understand the nature of human gastric dysrhythmias.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.